Does sex in the early period after circumcision increase HIV-seroconversion risk? Pooled analysis of adult male circumcision clinical trials
To evaluate whether sexual intercourse soon after adult male circumcision affected HIV risk. Combined analysis of data from African trials of men who were randomized to and underwent circumcision. We examined two associations: early sex (intercourse
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| Veröffentlicht in: | AIDS (London) 2009-07, Vol.23 (12), p.1557-1564 |
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| creator | MEHTA, Supriya D GRAY, Ronald H WAWER, Maria J BAILEY, Robert C AUVERT, Bertran MOSES, Stephen KIGOZI, Godfrey TALJAARD, Dirk PUREN, Adrien AGOT, Kawango SERWADDA, David PARKER, Corette B |
| description | To evaluate whether sexual intercourse soon after adult male circumcision affected HIV risk.
Combined analysis of data from African trials of men who were randomized to and underwent circumcision.
We examined two associations: early sex (intercourse |
| doi_str_mv | 10.1097/QAD.0b013e32832afe95 |
| format | Article |
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Combined analysis of data from African trials of men who were randomized to and underwent circumcision.
We examined two associations: early sex (intercourse <42 days after circumcision) and HIV acquisition at 3 months for the Orange Farm and Kisumu trials and at 6 months for the Rakai and Kisumu trials and incomplete wound healing at 1 month and seroconversion at 3 and 6 months for the Kisumu trial and at 6 months for the Rakai trial.
Early sex was reported by 3.9% of participants in Kisumu, 5.4% in Rakai, and 22.5% in Orange Farm. HIV seroprevalence was 0.0% at 3 months and 1.9% at 6 months among 18-24-year-olds reporting early sex and 0.2% at 3 months and 0.6% at 6 months among those who did not report early sex. In pooled analyses, men reporting early sex did not have higher HIV infection risk at 3 or 6 months. In Kisumu, 16 (1.3%) men had incomplete wound healing at the 30-day visit. One (6.3%) of these seroconverted at 3 months compared with 2 (0.2%) of 1246 men with complete wound healing (P = 0.075). No association was observed between incomplete wound healing and seroconversion for Rakai participants.
Most men delayed intercourse after circumcision. Early sex after circumcision was not associated with HIV risk, although the study power was limited. Nevertheless, men should delay intercourse to limit the potential for increased HIV risk until complete wound healing.</description><identifier>ISSN: 0269-9370</identifier><identifier>ISSN: 1473-5571</identifier><identifier>EISSN: 1473-5571</identifier><identifier>DOI: 10.1097/QAD.0b013e32832afe95</identifier><identifier>PMID: 19571722</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adolescent ; Biological and medical sciences ; Circumcision, Male - adverse effects ; Coitus ; Follow-Up Studies ; HIV Infections - prevention & control ; HIV Seropositivity - transmission ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infectious diseases ; Male ; Medical sciences ; Postoperative Period ; Randomized Controlled Trials as Topic ; Risk Assessment ; Sexual Behavior ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Wound Healing ; Young Adult</subject><ispartof>AIDS (London), 2009-07, Vol.23 (12), p.1557-1564</ispartof><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-30ab70e41bad406a06de1cf940c2efb741518ccf74c88b970a2f8e5c813dcc203</citedby><cites>FETCH-LOGICAL-c467t-30ab70e41bad406a06de1cf940c2efb741518ccf74c88b970a2f8e5c813dcc203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21784691$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19571722$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MEHTA, Supriya D</creatorcontrib><creatorcontrib>GRAY, Ronald H</creatorcontrib><creatorcontrib>WAWER, Maria J</creatorcontrib><creatorcontrib>BAILEY, Robert C</creatorcontrib><creatorcontrib>AUVERT, Bertran</creatorcontrib><creatorcontrib>MOSES, Stephen</creatorcontrib><creatorcontrib>KIGOZI, Godfrey</creatorcontrib><creatorcontrib>TALJAARD, Dirk</creatorcontrib><creatorcontrib>PUREN, Adrien</creatorcontrib><creatorcontrib>AGOT, Kawango</creatorcontrib><creatorcontrib>SERWADDA, David</creatorcontrib><creatorcontrib>PARKER, Corette B</creatorcontrib><title>Does sex in the early period after circumcision increase HIV-seroconversion risk? Pooled analysis of adult male circumcision clinical trials</title><title>AIDS (London)</title><addtitle>AIDS</addtitle><description>To evaluate whether sexual intercourse soon after adult male circumcision affected HIV risk.
Combined analysis of data from African trials of men who were randomized to and underwent circumcision.
We examined two associations: early sex (intercourse <42 days after circumcision) and HIV acquisition at 3 months for the Orange Farm and Kisumu trials and at 6 months for the Rakai and Kisumu trials and incomplete wound healing at 1 month and seroconversion at 3 and 6 months for the Kisumu trial and at 6 months for the Rakai trial.
Early sex was reported by 3.9% of participants in Kisumu, 5.4% in Rakai, and 22.5% in Orange Farm. HIV seroprevalence was 0.0% at 3 months and 1.9% at 6 months among 18-24-year-olds reporting early sex and 0.2% at 3 months and 0.6% at 6 months among those who did not report early sex. In pooled analyses, men reporting early sex did not have higher HIV infection risk at 3 or 6 months. In Kisumu, 16 (1.3%) men had incomplete wound healing at the 30-day visit. One (6.3%) of these seroconverted at 3 months compared with 2 (0.2%) of 1246 men with complete wound healing (P = 0.075). No association was observed between incomplete wound healing and seroconversion for Rakai participants.
Most men delayed intercourse after circumcision. Early sex after circumcision was not associated with HIV risk, although the study power was limited. Nevertheless, men should delay intercourse to limit the potential for increased HIV risk until complete wound healing.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Circumcision, Male - adverse effects</subject><subject>Coitus</subject><subject>Follow-Up Studies</subject><subject>HIV Infections - prevention & control</subject><subject>HIV Seropositivity - transmission</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Postoperative Period</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Risk Assessment</subject><subject>Sexual Behavior</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Wound Healing</subject><subject>Young Adult</subject><issn>0269-9370</issn><issn>1473-5571</issn><issn>1473-5571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1TAQhS0EopfCGyDkDexSxj-JnQ2oaoFWqgRIwNZynDE1OPHFTiruO_DQGHpVKBtWs5jvHM2cQ8hjBkcMevX8_fHpEQzABAquBbce-_YO2TCpRNO2it0lG-Bd3_RCwQF5UMoXAGhB6_vkgPUVUJxvyI_ThIUW_E7DTJdLpGhz3NEt5pBGav2CmbqQ3Tq5UEKaK-Yy2oL07PxTUzAnl-YrzL93OZSvL-m7lCJW7WzjroRCk6d2XONCJxvxtpmLYQ7ORrrkYGN5SO75OvDRfh6Sj69ffTg5ay7evjk_Ob5onOzU0giwgwKUbLCjhM5CNyJzvpfgOPpBSdYy7ZxX0mk99Aos9xpbp5kYneMgDsmLa9_tOkw4OpyXbKPZ5jDZvDPJBnN7M4dL8zldGa4Uh1ZUg2d7g5y-rVgWM4XiMEY7Y1qL6VTLJGPwX5ADF5pzXkF5DbqcSsnob65hYH71bWrf5t--q-zJ35_8Ee0LrsDTPWBLDdpnO9fsbzjOlJZdz8RPeTm5HA</recordid><startdate>20090731</startdate><enddate>20090731</enddate><creator>MEHTA, Supriya D</creator><creator>GRAY, Ronald H</creator><creator>WAWER, Maria J</creator><creator>BAILEY, Robert C</creator><creator>AUVERT, Bertran</creator><creator>MOSES, Stephen</creator><creator>KIGOZI, Godfrey</creator><creator>TALJAARD, Dirk</creator><creator>PUREN, Adrien</creator><creator>AGOT, Kawango</creator><creator>SERWADDA, David</creator><creator>PARKER, Corette B</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7T5</scope><scope>7U1</scope><scope>7U2</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090731</creationdate><title>Does sex in the early period after circumcision increase HIV-seroconversion risk? Pooled analysis of adult male circumcision clinical trials</title><author>MEHTA, Supriya D ; GRAY, Ronald H ; WAWER, Maria J ; BAILEY, Robert C ; AUVERT, Bertran ; MOSES, Stephen ; KIGOZI, Godfrey ; TALJAARD, Dirk ; PUREN, Adrien ; AGOT, Kawango ; SERWADDA, David ; PARKER, Corette B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-30ab70e41bad406a06de1cf940c2efb741518ccf74c88b970a2f8e5c813dcc203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Circumcision, Male - adverse effects</topic><topic>Coitus</topic><topic>Follow-Up Studies</topic><topic>HIV Infections - prevention & control</topic><topic>HIV Seropositivity - transmission</topic><topic>Human immunodeficiency virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Postoperative Period</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Risk Assessment</topic><topic>Sexual Behavior</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Wound Healing</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MEHTA, Supriya D</creatorcontrib><creatorcontrib>GRAY, Ronald H</creatorcontrib><creatorcontrib>WAWER, Maria J</creatorcontrib><creatorcontrib>BAILEY, Robert C</creatorcontrib><creatorcontrib>AUVERT, Bertran</creatorcontrib><creatorcontrib>MOSES, Stephen</creatorcontrib><creatorcontrib>KIGOZI, Godfrey</creatorcontrib><creatorcontrib>TALJAARD, Dirk</creatorcontrib><creatorcontrib>PUREN, Adrien</creatorcontrib><creatorcontrib>AGOT, Kawango</creatorcontrib><creatorcontrib>SERWADDA, David</creatorcontrib><creatorcontrib>PARKER, Corette B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>AIDS (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MEHTA, Supriya D</au><au>GRAY, Ronald H</au><au>WAWER, Maria J</au><au>BAILEY, Robert C</au><au>AUVERT, Bertran</au><au>MOSES, Stephen</au><au>KIGOZI, Godfrey</au><au>TALJAARD, Dirk</au><au>PUREN, Adrien</au><au>AGOT, Kawango</au><au>SERWADDA, David</au><au>PARKER, Corette B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does sex in the early period after circumcision increase HIV-seroconversion risk? Pooled analysis of adult male circumcision clinical trials</atitle><jtitle>AIDS (London)</jtitle><addtitle>AIDS</addtitle><date>2009-07-31</date><risdate>2009</risdate><volume>23</volume><issue>12</issue><spage>1557</spage><epage>1564</epage><pages>1557-1564</pages><issn>0269-9370</issn><issn>1473-5571</issn><eissn>1473-5571</eissn><abstract>To evaluate whether sexual intercourse soon after adult male circumcision affected HIV risk.
Combined analysis of data from African trials of men who were randomized to and underwent circumcision.
We examined two associations: early sex (intercourse <42 days after circumcision) and HIV acquisition at 3 months for the Orange Farm and Kisumu trials and at 6 months for the Rakai and Kisumu trials and incomplete wound healing at 1 month and seroconversion at 3 and 6 months for the Kisumu trial and at 6 months for the Rakai trial.
Early sex was reported by 3.9% of participants in Kisumu, 5.4% in Rakai, and 22.5% in Orange Farm. HIV seroprevalence was 0.0% at 3 months and 1.9% at 6 months among 18-24-year-olds reporting early sex and 0.2% at 3 months and 0.6% at 6 months among those who did not report early sex. In pooled analyses, men reporting early sex did not have higher HIV infection risk at 3 or 6 months. In Kisumu, 16 (1.3%) men had incomplete wound healing at the 30-day visit. One (6.3%) of these seroconverted at 3 months compared with 2 (0.2%) of 1246 men with complete wound healing (P = 0.075). No association was observed between incomplete wound healing and seroconversion for Rakai participants.
Most men delayed intercourse after circumcision. Early sex after circumcision was not associated with HIV risk, although the study power was limited. Nevertheless, men should delay intercourse to limit the potential for increased HIV risk until complete wound healing.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>19571722</pmid><doi>10.1097/QAD.0b013e32832afe95</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0269-9370 |
| ispartof | AIDS (London), 2009-07, Vol.23 (12), p.1557-1564 |
| issn | 0269-9370 1473-5571 1473-5571 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Biological and medical sciences Circumcision, Male - adverse effects Coitus Follow-Up Studies HIV Infections - prevention & control HIV Seropositivity - transmission Human immunodeficiency virus Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Male Medical sciences Postoperative Period Randomized Controlled Trials as Topic Risk Assessment Sexual Behavior Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Wound Healing Young Adult |
| title | Does sex in the early period after circumcision increase HIV-seroconversion risk? Pooled analysis of adult male circumcision clinical trials |
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