Single Nucleotide Polymorphisms, Apoptosis, and the Development of Severe Late Adverse Effects After Radiotherapy

Purpose: Evidence has accumulated in recent years suggestive of a genetic basis for a susceptibility to the development of radiation injury after cancer radiotherapy. The purpose of this study was to assess whether patients with severe radiation-induced sequelae (RIS; i.e., National Cancer Institute...

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Veröffentlicht in:	Clinical cancer research 2008-10, Vol.14 (19), p.6284-6288
Hauptverfasser:	AZRIA, David, OZSAHIN, Mahmut, ROSENSTEIN, Barry S, KRAMAR, Andrew, PETERS, Sheila, ATENCIO, David P, CROMPTON, Nigel E. A, MORNEX, Francoise, PELEGRIN, André, DUBOIS, Jean-Bernard, MIRIMANOFF, René-Olivier
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Apoptosis Biological and medical sciences Cancer Case-Control Studies CD8-Positive T-Lymphocytes - metabolism Fibrosis Genetic Predisposition to Disease Genotype Humans Life Sciences Medical sciences Neoplasms - genetics Neoplasms - pathology Neoplasms - radiotherapy Pharmacology. Drug treatments Polymorphism, Single Nucleotide radiation Radiation Injuries - diagnosis Radiation Injuries - genetics Radiation Tolerance - genetics Radiotherapy - adverse effects Risk SNPs Time Factors Treatment Outcome
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