The first 30 years of p53: growing ever more complex

When p53 was first discovered, it received relatively little attention from cancer researchers. The road leading to p53's rise to fame, and the recognition of TP53 as the most frequently altered gene in human cancer, has been long and winding. This Timeline examines the rich history of this piv...

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Veröffentlicht in:	Nature reviews. Cancer 2009-10, Vol.9 (10), p.749-758
Hauptverfasser:	Levine, Arnold J., Oren, Moshe
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biomedical and Life Sciences Biomedicine Cancer Cancer Research Cell cycle Control Cytokines DNA Embryos Genes, p53 - genetics Genetic aspects Health aspects History, 20th Century History, 21st Century Humans Metabolic pathways Neoplasms - genetics Neoplasms - physiopathology Oncogenes p53 protein Physiological aspects Senescence Simian virus 40 Stress SV40 (Virus) timeline Transcription factors Tumor proteins Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - physiology
Online-Zugang:	Volltext
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