Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2

The apoptotic initiator caspase‐2 has been implicated in oocyte death, in DNA damage‐ and heat shock‐induced death, and in mitotic catastrophe. We show here that the mitosis‐promoting kinase, cdk1–cyclin B1, suppresses apoptosis upstream of mitochondrial cytochrome c release by phosphorylating caspa...

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Veröffentlicht in:	The EMBO journal 2009-10, Vol.28 (20), p.3216-3227
Hauptverfasser:	Andersen, Joshua L, Johnson, Carrie E, Freel, Christopher D, Parrish, Amanda B, Day, Jennifer L, Buchakjian, Marisa R, Nutt, Leta K, Thompson, J Will, Moseley, M Arthur, Kornbluth, Sally
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - genetics Apoptosis - physiology Caspase 2 - genetics Caspase 2 - metabolism caspase-2 CDC2 Protein Kinase - genetics CDC2 Protein Kinase - metabolism cdk1 Cell division Cell Line Cell Line, Tumor Cyclin B - genetics Cyclin B - metabolism Cyclin B1 Cytochrome Deoxyribonucleic acid DNA Electrophoresis, Polyacrylamide Gel EMBO06 EMBO07 Evolutionary biology Genetic Vectors Humans Kinases Lentivirus mitosis Mitosis - drug effects Mitosis - genetics Mitosis - physiology Molecular biology Mortality Nocodazole - pharmacology Oocytes Phosphorylation RNA, Small Interfering Serine - genetics Serine - metabolism Serine - physiology Xenopus
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