Clinical efficacy and safety of abatacept in methotrexate-naive patients with early rheumatoid arthritis and poor prognostic factors

Objectives:To assess the efficacy and safety of abatacept in methotrexate-naive patients with early rheumatoid arthritis (RA) and poor prognostic factors.Methods:In this double-blind, phase IIIb study, patients with RA for 2 years or less were randomly assigned 1 : 1 to receive abatacept (∼10 mg/kg)...

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Veröffentlicht in:	Annals of the rheumatic diseases 2009-12, Vol.68 (12), p.1870-1877
Hauptverfasser:	Westhovens, R, Robles, M, Ximenes, A C, Nayiager, S, Wollenhaupt, J, Durez, P, Gomez-Reino, J, Grassi, W, Haraoui, B, Shergy, W, Park, S-H, Genant, H, Peterfy, C, Becker, J-C, Covucci, A, Helfrick, R, Bathon, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Abatacept Adult Antirheumatic Agents - adverse effects Antirheumatic Agents - therapeutic use Arthritis, Rheumatoid - diagnostic imaging Arthritis, Rheumatoid - drug therapy Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Clinical and Epidemiological Research Disease control Disease Progression Diseases of the osteoarticular system Drug Therapy, Combination Epidemiologic Methods Female Humans Immunoconjugates - adverse effects Immunoconjugates - therapeutic use Immunomodulators Immunosuppressive Agents - therapeutic use Inflammatory joint diseases Lymphocytes Male Medical prognosis Medical sciences Methotrexate Methotrexate - adverse effects Methotrexate - therapeutic use Middle Aged Pharmacology. Drug treatments Prognosis Proteins Quality of Life Radiography Rheumatoid arthritis Treatment Outcome Tuberculosis
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