Neutralization of Vascular Endothelial Growth Factor Antiangiogenic Isoforms Is More Effective Than Treatment with Proangiogenic Isoforms in Stimulating Vascular Development and Follicle Progression in the Perinatal Rat Ovary

Inhibition of vascular endothelial growth factor A (VEGFA) signal transduction arrests vascular and follicle development. Because antiangiogenic VEGFA isoforms are proposed to block proangiogenic VEGFA isoforms from binding to their receptors, we hypothesized that proangiogenic isoforms promote and...

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Veröffentlicht in:	Biology of reproduction 2009-11, Vol.81 (5), p.978-988
Hauptverfasser:	Artac, Robin A, McFee, Renee M, Longfellow Smith, Robyn A, Baltes-Breitwisch, Michelle M, Clopton, Debra T, Cupp, Andrea S
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Antibodies, Neutralizing Female Immunohistochemistry Neovascularization, Physiologic - drug effects Organ Culture Techniques Ovarian Follicle - drug effects Ovarian Follicle - growth & development Ovarian Follicle - metabolism Ovary - drug effects Ovary - growth & development Ovary - metabolism Protein Isoforms - metabolism Rats Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor A - pharmacology
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