Microstimulation of macaque area LIP affects decision-making in a motion discrimination task
A central goal of cognitive neuroscience is to elucidate the neural mechanisms underlying decision-making. Recent physiological studies suggest that neurons in association areas may be involved in this process. To test this, we measured the effects of electrical microstimulation in the lateral intra...
Gespeichert in:
| Veröffentlicht in: | Nature neuroscience 2006-05, Vol.9 (5), p.682-689 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 689 |
|---|---|
| container_issue | 5 |
| container_start_page | 682 |
| container_title | Nature neuroscience |
| container_volume | 9 |
| creator | Hanks, Timothy D Ditterich, Jochen Shadlen, Michael N |
| description | A central goal of cognitive neuroscience is to elucidate the neural mechanisms underlying decision-making. Recent physiological studies suggest that neurons in association areas may be involved in this process. To test this, we measured the effects of electrical microstimulation in the lateral intraparietal area (LIP) while monkeys performed a reaction-time motion discrimination task with a saccadic response. In each experiment, we identified a cluster of LIP cells with overlapping response fields (RFs) and sustained activity during memory-guided saccades. Microstimulation of this cluster caused an increase in the proportion of choices toward the RF of the stimulated neurons. Choices toward the stimulated RF were faster with microstimulation, while choices in the opposite direction were slower. Microstimulation never directly evoked saccades, nor did it change reaction times in a simple saccade task. These results demonstrate that the discharge of LIP neurons is causally related to decision formation in the discrimination task. |
| doi_str_mv | 10.1038/nn1683 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2770004</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A185536872</galeid><sourcerecordid>A185536872</sourcerecordid><originalsourceid>FETCH-LOGICAL-c625t-b9d5d73e1e8e93a2673ea047aa89ef3ed14d56ea924017c6e32331b891623a1f3</originalsourceid><addsrcrecordid>eNqFkltv1DAQhSMEoqXAT0ARDyAeUuz4_oJUVVxWWgTi8oZkzSaT4DaxS5wg-PdM2RXL9gHkB1ueb47OHE1RPOTslDNhn8fItRW3imOupK64qfVtejNnKl0rfVTcy_mCMWaUdXeLI641k0y74-LL29BMKc9hXAaYQ4pl6soRGvi2YAkTQrlevS-h67CZc9liEzJB1QiXIfZliCWUY_rd14bcTGEMcSszQ768X9zpYMj4YHefFJ9fvfx0_qZav3u9Oj9bVw2Zm6uNa1VrBHK06ATUmt7ApAGwDjuBLZet0giuloybRqOoheAb67iuBfBOnBQvtrpXy2bEtsE4TzD4K7ID00-fIPjDSgxffZ---9oYCkWSwNOdwJRo8Dz7kabBYYCIacnecqOZqK0i8sk_SW0c00rK_4LccOuUsQQ-vgFepGWKlBfZk5pbIR1Bp1uohwF9iF2iORo6LY6hSRG7QP9n3ColtDU1NTw7aCBmxh9zD0vOfvXxwyG7s3q9CXnC7k9ynPnr7fLb7SLw0d8577HdOu1zzFSKPU77WW5I_QJlLtYo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>274618349</pqid></control><display><type>article</type><title>Microstimulation of macaque area LIP affects decision-making in a motion discrimination task</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><source>Nature Journals Online</source><creator>Hanks, Timothy D ; Ditterich, Jochen ; Shadlen, Michael N</creator><creatorcontrib>Hanks, Timothy D ; Ditterich, Jochen ; Shadlen, Michael N</creatorcontrib><description>A central goal of cognitive neuroscience is to elucidate the neural mechanisms underlying decision-making. Recent physiological studies suggest that neurons in association areas may be involved in this process. To test this, we measured the effects of electrical microstimulation in the lateral intraparietal area (LIP) while monkeys performed a reaction-time motion discrimination task with a saccadic response. In each experiment, we identified a cluster of LIP cells with overlapping response fields (RFs) and sustained activity during memory-guided saccades. Microstimulation of this cluster caused an increase in the proportion of choices toward the RF of the stimulated neurons. Choices toward the stimulated RF were faster with microstimulation, while choices in the opposite direction were slower. Microstimulation never directly evoked saccades, nor did it change reaction times in a simple saccade task. These results demonstrate that the discharge of LIP neurons is causally related to decision formation in the discrimination task.</description><identifier>ISSN: 1097-6256</identifier><identifier>EISSN: 1546-1726</identifier><identifier>DOI: 10.1038/nn1683</identifier><identifier>PMID: 16604069</identifier><identifier>CODEN: NANEFN</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Action Potentials - physiology ; Action Potentials - radiation effects ; Animal Genetics and Genomics ; Animals ; Behavior, Animal ; Behavioral Sciences ; Biological Techniques ; Biomedical and Life Sciences ; Biomedicine ; Decision making ; Decision Making - physiology ; Decision Making - radiation effects ; Discrimination, Psychological - physiology ; Discrimination, Psychological - radiation effects ; Electric Stimulation - methods ; Influence ; Macaca ; Macaca mulatta ; Motion Perception - drug effects ; Motion Perception - physiology ; Neural stimulation ; Neurobiology ; Neurons ; Neurons - physiology ; Neurons - radiation effects ; Neurosciences ; Parietal Lobe - cytology ; Photic Stimulation - methods ; Physiological aspects ; Reaction Time - physiology ; Reaction Time - radiation effects ; Saccades - physiology</subject><ispartof>Nature neuroscience, 2006-05, Vol.9 (5), p.682-689</ispartof><rights>Springer Nature America, Inc. 2006</rights><rights>COPYRIGHT 2006 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group May 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c625t-b9d5d73e1e8e93a2673ea047aa89ef3ed14d56ea924017c6e32331b891623a1f3</citedby><cites>FETCH-LOGICAL-c625t-b9d5d73e1e8e93a2673ea047aa89ef3ed14d56ea924017c6e32331b891623a1f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nn1683$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nn1683$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16604069$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hanks, Timothy D</creatorcontrib><creatorcontrib>Ditterich, Jochen</creatorcontrib><creatorcontrib>Shadlen, Michael N</creatorcontrib><title>Microstimulation of macaque area LIP affects decision-making in a motion discrimination task</title><title>Nature neuroscience</title><addtitle>Nat Neurosci</addtitle><addtitle>Nat Neurosci</addtitle><description>A central goal of cognitive neuroscience is to elucidate the neural mechanisms underlying decision-making. Recent physiological studies suggest that neurons in association areas may be involved in this process. To test this, we measured the effects of electrical microstimulation in the lateral intraparietal area (LIP) while monkeys performed a reaction-time motion discrimination task with a saccadic response. In each experiment, we identified a cluster of LIP cells with overlapping response fields (RFs) and sustained activity during memory-guided saccades. Microstimulation of this cluster caused an increase in the proportion of choices toward the RF of the stimulated neurons. Choices toward the stimulated RF were faster with microstimulation, while choices in the opposite direction were slower. Microstimulation never directly evoked saccades, nor did it change reaction times in a simple saccade task. These results demonstrate that the discharge of LIP neurons is causally related to decision formation in the discrimination task.</description><subject>Action Potentials - physiology</subject><subject>Action Potentials - radiation effects</subject><subject>Animal Genetics and Genomics</subject><subject>Animals</subject><subject>Behavior, Animal</subject><subject>Behavioral Sciences</subject><subject>Biological Techniques</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Decision making</subject><subject>Decision Making - physiology</subject><subject>Decision Making - radiation effects</subject><subject>Discrimination, Psychological - physiology</subject><subject>Discrimination, Psychological - radiation effects</subject><subject>Electric Stimulation - methods</subject><subject>Influence</subject><subject>Macaca</subject><subject>Macaca mulatta</subject><subject>Motion Perception - drug effects</subject><subject>Motion Perception - physiology</subject><subject>Neural stimulation</subject><subject>Neurobiology</subject><subject>Neurons</subject><subject>Neurons - physiology</subject><subject>Neurons - radiation effects</subject><subject>Neurosciences</subject><subject>Parietal Lobe - cytology</subject><subject>Photic Stimulation - methods</subject><subject>Physiological aspects</subject><subject>Reaction Time - physiology</subject><subject>Reaction Time - radiation effects</subject><subject>Saccades - physiology</subject><issn>1097-6256</issn><issn>1546-1726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkltv1DAQhSMEoqXAT0ARDyAeUuz4_oJUVVxWWgTi8oZkzSaT4DaxS5wg-PdM2RXL9gHkB1ueb47OHE1RPOTslDNhn8fItRW3imOupK64qfVtejNnKl0rfVTcy_mCMWaUdXeLI641k0y74-LL29BMKc9hXAaYQ4pl6soRGvi2YAkTQrlevS-h67CZc9liEzJB1QiXIfZliCWUY_rd14bcTGEMcSszQ768X9zpYMj4YHefFJ9fvfx0_qZav3u9Oj9bVw2Zm6uNa1VrBHK06ATUmt7ApAGwDjuBLZet0giuloybRqOoheAb67iuBfBOnBQvtrpXy2bEtsE4TzD4K7ID00-fIPjDSgxffZ---9oYCkWSwNOdwJRo8Dz7kabBYYCIacnecqOZqK0i8sk_SW0c00rK_4LccOuUsQQ-vgFepGWKlBfZk5pbIR1Bp1uohwF9iF2iORo6LY6hSRG7QP9n3ColtDU1NTw7aCBmxh9zD0vOfvXxwyG7s3q9CXnC7k9ynPnr7fLb7SLw0d8577HdOu1zzFSKPU77WW5I_QJlLtYo</recordid><startdate>20060501</startdate><enddate>20060501</enddate><creator>Hanks, Timothy D</creator><creator>Ditterich, Jochen</creator><creator>Shadlen, Michael N</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20060501</creationdate><title>Microstimulation of macaque area LIP affects decision-making in a motion discrimination task</title><author>Hanks, Timothy D ; Ditterich, Jochen ; Shadlen, Michael N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c625t-b9d5d73e1e8e93a2673ea047aa89ef3ed14d56ea924017c6e32331b891623a1f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Action Potentials - physiology</topic><topic>Action Potentials - radiation effects</topic><topic>Animal Genetics and Genomics</topic><topic>Animals</topic><topic>Behavior, Animal</topic><topic>Behavioral Sciences</topic><topic>Biological Techniques</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Decision making</topic><topic>Decision Making - physiology</topic><topic>Decision Making - radiation effects</topic><topic>Discrimination, Psychological - physiology</topic><topic>Discrimination, Psychological - radiation effects</topic><topic>Electric Stimulation - methods</topic><topic>Influence</topic><topic>Macaca</topic><topic>Macaca mulatta</topic><topic>Motion Perception - drug effects</topic><topic>Motion Perception - physiology</topic><topic>Neural stimulation</topic><topic>Neurobiology</topic><topic>Neurons</topic><topic>Neurons - physiology</topic><topic>Neurons - radiation effects</topic><topic>Neurosciences</topic><topic>Parietal Lobe - cytology</topic><topic>Photic Stimulation - methods</topic><topic>Physiological aspects</topic><topic>Reaction Time - physiology</topic><topic>Reaction Time - radiation effects</topic><topic>Saccades - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hanks, Timothy D</creatorcontrib><creatorcontrib>Ditterich, Jochen</creatorcontrib><creatorcontrib>Shadlen, Michael N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nature neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hanks, Timothy D</au><au>Ditterich, Jochen</au><au>Shadlen, Michael N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microstimulation of macaque area LIP affects decision-making in a motion discrimination task</atitle><jtitle>Nature neuroscience</jtitle><stitle>Nat Neurosci</stitle><addtitle>Nat Neurosci</addtitle><date>2006-05-01</date><risdate>2006</risdate><volume>9</volume><issue>5</issue><spage>682</spage><epage>689</epage><pages>682-689</pages><issn>1097-6256</issn><eissn>1546-1726</eissn><coden>NANEFN</coden><abstract>A central goal of cognitive neuroscience is to elucidate the neural mechanisms underlying decision-making. Recent physiological studies suggest that neurons in association areas may be involved in this process. To test this, we measured the effects of electrical microstimulation in the lateral intraparietal area (LIP) while monkeys performed a reaction-time motion discrimination task with a saccadic response. In each experiment, we identified a cluster of LIP cells with overlapping response fields (RFs) and sustained activity during memory-guided saccades. Microstimulation of this cluster caused an increase in the proportion of choices toward the RF of the stimulated neurons. Choices toward the stimulated RF were faster with microstimulation, while choices in the opposite direction were slower. Microstimulation never directly evoked saccades, nor did it change reaction times in a simple saccade task. These results demonstrate that the discharge of LIP neurons is causally related to decision formation in the discrimination task.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>16604069</pmid><doi>10.1038/nn1683</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1097-6256 |
| ispartof | Nature neuroscience, 2006-05, Vol.9 (5), p.682-689 |
| issn | 1097-6256 1546-1726 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2770004 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online |
| subjects | Action Potentials - physiology Action Potentials - radiation effects Animal Genetics and Genomics Animals Behavior, Animal Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Decision making Decision Making - physiology Decision Making - radiation effects Discrimination, Psychological - physiology Discrimination, Psychological - radiation effects Electric Stimulation - methods Influence Macaca Macaca mulatta Motion Perception - drug effects Motion Perception - physiology Neural stimulation Neurobiology Neurons Neurons - physiology Neurons - radiation effects Neurosciences Parietal Lobe - cytology Photic Stimulation - methods Physiological aspects Reaction Time - physiology Reaction Time - radiation effects Saccades - physiology |
| title | Microstimulation of macaque area LIP affects decision-making in a motion discrimination task |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T09%3A36%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Microstimulation%20of%20macaque%20area%20LIP%20affects%20decision-making%20in%20a%20motion%20discrimination%20task&rft.jtitle=Nature%20neuroscience&rft.au=Hanks,%20Timothy%20D&rft.date=2006-05-01&rft.volume=9&rft.issue=5&rft.spage=682&rft.epage=689&rft.pages=682-689&rft.issn=1097-6256&rft.eissn=1546-1726&rft.coden=NANEFN&rft_id=info:doi/10.1038/nn1683&rft_dat=%3Cgale_pubme%3EA185536872%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=274618349&rft_id=info:pmid/16604069&rft_galeid=A185536872&rfr_iscdi=true |