T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow

During a screen for ethylnitrosourea-induced mutations in mice affecting blood natural killer (NK) cells, we identified a strain, designated Duane, in which NK cells were reduced in blood and spleen but increased in lymph nodes (LNs) and bone marrow (BM). The accumulation of NK cells in LNs reflecte...

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Veröffentlicht in:	The Journal of experimental medicine 2009-10, Vol.206 (11), p.2469-2481
Hauptverfasser:	Jenne, Craig N, Enders, Anselm, Rivera, Richard, Watson, Susan R, Bankovich, Alexander J, Pereira, Joao P, Xu, Ying, Roots, Carla M, Beilke, Joshua N, Banerjee, Arnob, Reiner, Steven L, Miller, Sara A, Weinmann, Amy S, Goodnow, Chris C, Lanier, Lewis L, Cyster, Jason G, Chun, Jerold
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow Cells - cytology Bone Marrow Cells - drug effects Cell Count Cell Movement - drug effects Ethylnitrosourea Fingolimod Hydrochloride Killer Cells, Natural - cytology Killer Cells, Natural - drug effects Killer Cells, Natural - metabolism Lymph Nodes - cytology Lymph Nodes - drug effects Lymphocyte Activation - drug effects Lysophospholipids - deficiency Lysophospholipids - pharmacology Mice Mice, Mutant Strains Mutation - genetics Propylene Glycols - pharmacology Receptors, Lysosphingolipid - metabolism Sphingosine - analogs & derivatives Sphingosine - deficiency Sphingosine - pharmacology T-Box Domain Proteins - metabolism
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