Design and modification of EGF4KDEL 7Mut, a novel bispecific ligand-directed toxin, with decreased immunogenicity and potent anti-mesothelioma activity

Background: Potency, immunogenicity, and toxicity are three problems that limit the use of targeted toxins in solid tumour therapy. Methods: To address potency, we used genetic engineering to develop a novel bispecific ligand-directed toxin (BLT) called EGF4KDEL, a novel recombinant anti-mesotheliom...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of cancer 2009-10, Vol.101 (7), p.1114-1123
Hauptverfasser:	Stish, B J, Oh, S, Chen, H, Dudek, A Z, Kratzke, R A, Vallera, D A
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP Ribose Transferases - therapeutic use Animals Bacterial Toxins - therapeutic use Biological and medical sciences Biological products Biomedical and Life Sciences Biomedicine Cancer Research Cancer therapies Cell Line, Tumor Cytokines Drug Resistance Epidemiology Epidermal growth factor Epidermal Growth Factor - therapeutic use Exotoxins - therapeutic use Female Genetic engineering Humans Immunotoxins - immunology Immunotoxins - therapeutic use Interleukin-4 - therapeutic use Ligands Male Medical prognosis Medical research Medical sciences Mesothelioma Mesothelioma - drug therapy Mice Mice, Inbred BALB C Molecular Medicine Oncology Peritoneal Neoplasms - drug therapy Pseudomonas aeruginosa Exotoxin A Radiation Recombinant Proteins - therapeutic use Toxicity Toxins Translational Therapeutics Tumors Virulence Factors - therapeutic use Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!