The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro
Background: Fascin is overexpressed in many cancers, including colorectal, but its role in the malignant transformation of benign colorectal adenomas is unclear. Methods: Immunohistochemical analysis of fascin expression was carried out in resected human colorectal adenoma specimens. The effects of...
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| Veröffentlicht in: | British journal of cancer 2009-10, Vol.101 (7), p.1124-1129 |
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| creator | Qualtrough, D Singh, K Banu, N Paraskeva, C Pignatelli, M |
| description | Background:
Fascin is overexpressed in many cancers, including colorectal, but its role in the malignant transformation of benign colorectal adenomas is unclear.
Methods:
Immunohistochemical analysis of fascin expression was carried out in resected human colorectal adenoma specimens. The effects of forced overexpression of fascin on adenoma cell motility were also analysed.
Results:
We show fascin overexpression in adenomas increasing with tumour size, histological type, and degree of dysplasia and increased cell motility in adenoma cell lines following fascin transfection.
Conclusion:
These data suggest an important role for fascin in the malignant progression of colorectal tumours. |
| doi_str_mv | 10.1038/sj.bjc.6605286 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2768091</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1878200211</sourcerecordid><originalsourceid>FETCH-LOGICAL-c485t-15e4fe98c13bfa97bc20960fd82357d4f9ba3ac79317967d1fc671ac8e1405d73</originalsourceid><addsrcrecordid>eNp1kctr3DAQxkVpaLbbXnssptDevNHD1uNSKKGPQCCX9CxkWd7I2NJWYy_d_74ya5K2kIsGzfzmmxk-hN4RvCOYySvod01vd5zjmkr-Am1IzWhJJBUv0QZjLEqsKL5ErwH6_FVYilfokijBJCdsg073D64wdvKhbObQDj7si0OKk_Oh6AzYHDwU8eiS-31IDsC1Rc7ZOMTk7GSGwrQuxNFAYUK7tI65GYr8-sFPpwVeicK6YYAlcfRTim_QRWcGcG_XuEU_v329v_5R3t59v7n-clvaStZTSWpXdU5JS1jTGSUaS7HiuGslZbVoq041hhkrFCNCcdGSznJBjJWOVLhuBduiz2fdw9yMrrUuTMkM-pD8aNJJR-P1v5XgH_Q-HjUVXGJFssCnVSDFX7ODSY8elltMcHEGzUUeKLIbW_ThP7CPcwr5OE2pUqoidIF2Z8imCJBc97gJwXqxVEOvs6V6tTQ3vP97_yd89TADH1cg-2WGLplgPTxylBJMOasyd3XmIJfC3qWn9Z4Z_Qf0ur1h</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>229994120</pqid></control><display><type>article</type><title>The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Nature Journals Online</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Qualtrough, D ; Singh, K ; Banu, N ; Paraskeva, C ; Pignatelli, M</creator><creatorcontrib>Qualtrough, D ; Singh, K ; Banu, N ; Paraskeva, C ; Pignatelli, M</creatorcontrib><description>Background:
Fascin is overexpressed in many cancers, including colorectal, but its role in the malignant transformation of benign colorectal adenomas is unclear.
Methods:
Immunohistochemical analysis of fascin expression was carried out in resected human colorectal adenoma specimens. The effects of forced overexpression of fascin on adenoma cell motility were also analysed.
Results:
We show fascin overexpression in adenomas increasing with tumour size, histological type, and degree of dysplasia and increased cell motility in adenoma cell lines following fascin transfection.
Conclusion:
These data suggest an important role for fascin in the malignant progression of colorectal tumours.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/sj.bjc.6605286</identifier><identifier>PMID: 19738613</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adenoma - chemistry ; Adenoma - pathology ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Carrier Proteins - analysis ; Carrier Proteins - physiology ; Cell Line, Tumor ; Cell Movement ; Colorectal Neoplasms - chemistry ; Colorectal Neoplasms - pathology ; Disease Progression ; Drug Resistance ; Epidemiology ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Immunohistochemistry ; Medical research ; Medical sciences ; Microfilament Proteins - analysis ; Microfilament Proteins - physiology ; Molecular Medicine ; Motility ; Oncology ; Proteins ; Short Communication ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>British journal of cancer, 2009-10, Vol.101 (7), p.1124-1129</ispartof><rights>The Author(s) 2009</rights><rights>2009 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Oct 6, 2009</rights><rights>Copyright © 2009 Cancer Research UK 2009 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-15e4fe98c13bfa97bc20960fd82357d4f9ba3ac79317967d1fc671ac8e1405d73</citedby><cites>FETCH-LOGICAL-c485t-15e4fe98c13bfa97bc20960fd82357d4f9ba3ac79317967d1fc671ac8e1405d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768091/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768091/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22102634$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19738613$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qualtrough, D</creatorcontrib><creatorcontrib>Singh, K</creatorcontrib><creatorcontrib>Banu, N</creatorcontrib><creatorcontrib>Paraskeva, C</creatorcontrib><creatorcontrib>Pignatelli, M</creatorcontrib><title>The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background:
Fascin is overexpressed in many cancers, including colorectal, but its role in the malignant transformation of benign colorectal adenomas is unclear.
Methods:
Immunohistochemical analysis of fascin expression was carried out in resected human colorectal adenoma specimens. The effects of forced overexpression of fascin on adenoma cell motility were also analysed.
Results:
We show fascin overexpression in adenomas increasing with tumour size, histological type, and degree of dysplasia and increased cell motility in adenoma cell lines following fascin transfection.
Conclusion:
These data suggest an important role for fascin in the malignant progression of colorectal tumours.</description><subject>Adenoma - chemistry</subject><subject>Adenoma - pathology</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Carrier Proteins - analysis</subject><subject>Carrier Proteins - physiology</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement</subject><subject>Colorectal Neoplasms - chemistry</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Disease Progression</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Microfilament Proteins - analysis</subject><subject>Microfilament Proteins - physiology</subject><subject>Molecular Medicine</subject><subject>Motility</subject><subject>Oncology</subject><subject>Proteins</subject><subject>Short Communication</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tumors</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kctr3DAQxkVpaLbbXnssptDevNHD1uNSKKGPQCCX9CxkWd7I2NJWYy_d_74ya5K2kIsGzfzmmxk-hN4RvCOYySvod01vd5zjmkr-Am1IzWhJJBUv0QZjLEqsKL5ErwH6_FVYilfokijBJCdsg073D64wdvKhbObQDj7si0OKk_Oh6AzYHDwU8eiS-31IDsC1Rc7ZOMTk7GSGwrQuxNFAYUK7tI65GYr8-sFPpwVeicK6YYAlcfRTim_QRWcGcG_XuEU_v329v_5R3t59v7n-clvaStZTSWpXdU5JS1jTGSUaS7HiuGslZbVoq041hhkrFCNCcdGSznJBjJWOVLhuBduiz2fdw9yMrrUuTMkM-pD8aNJJR-P1v5XgH_Q-HjUVXGJFssCnVSDFX7ODSY8elltMcHEGzUUeKLIbW_ThP7CPcwr5OE2pUqoidIF2Z8imCJBc97gJwXqxVEOvs6V6tTQ3vP97_yd89TADH1cg-2WGLplgPTxylBJMOasyd3XmIJfC3qWn9Z4Z_Qf0ur1h</recordid><startdate>20091006</startdate><enddate>20091006</enddate><creator>Qualtrough, D</creator><creator>Singh, K</creator><creator>Banu, N</creator><creator>Paraskeva, C</creator><creator>Pignatelli, M</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20091006</creationdate><title>The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro</title><author>Qualtrough, D ; Singh, K ; Banu, N ; Paraskeva, C ; Pignatelli, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c485t-15e4fe98c13bfa97bc20960fd82357d4f9ba3ac79317967d1fc671ac8e1405d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adenoma - chemistry</topic><topic>Adenoma - pathology</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Carrier Proteins - analysis</topic><topic>Carrier Proteins - physiology</topic><topic>Cell Line, Tumor</topic><topic>Cell Movement</topic><topic>Colorectal Neoplasms - chemistry</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Disease Progression</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Microfilament Proteins - analysis</topic><topic>Microfilament Proteins - physiology</topic><topic>Molecular Medicine</topic><topic>Motility</topic><topic>Oncology</topic><topic>Proteins</topic><topic>Short Communication</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qualtrough, D</creatorcontrib><creatorcontrib>Singh, K</creatorcontrib><creatorcontrib>Banu, N</creatorcontrib><creatorcontrib>Paraskeva, C</creatorcontrib><creatorcontrib>Pignatelli, M</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qualtrough, D</au><au>Singh, K</au><au>Banu, N</au><au>Paraskeva, C</au><au>Pignatelli, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2009-10-06</date><risdate>2009</risdate><volume>101</volume><issue>7</issue><spage>1124</spage><epage>1129</epage><pages>1124-1129</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Background:
Fascin is overexpressed in many cancers, including colorectal, but its role in the malignant transformation of benign colorectal adenomas is unclear.
Methods:
Immunohistochemical analysis of fascin expression was carried out in resected human colorectal adenoma specimens. The effects of forced overexpression of fascin on adenoma cell motility were also analysed.
Results:
We show fascin overexpression in adenomas increasing with tumour size, histological type, and degree of dysplasia and increased cell motility in adenoma cell lines following fascin transfection.
Conclusion:
These data suggest an important role for fascin in the malignant progression of colorectal tumours.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>19738613</pmid><doi>10.1038/sj.bjc.6605286</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenoma - chemistry Adenoma - pathology Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Carrier Proteins - analysis Carrier Proteins - physiology Cell Line, Tumor Cell Movement Colorectal Neoplasms - chemistry Colorectal Neoplasms - pathology Disease Progression Drug Resistance Epidemiology Gastroenterology. Liver. Pancreas. Abdomen Humans Immunohistochemistry Medical research Medical sciences Microfilament Proteins - analysis Microfilament Proteins - physiology Molecular Medicine Motility Oncology Proteins Short Communication Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro |
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