Induction of Protein Tyrosine Kinase 6 in Mouse Intestinal Crypt Epithelial Cells Promotes DNA Damage–Induced Apoptosis

Background & Aims Protein tyrosine kinase 6 (PTK6) is expressed in epithelial linings of the gastrointestinal tract. PTK6 sensitizes the nontransformed Rat1a fibroblast cell line to apoptotic stimuli. The aim of this study was to determine if PTK6 regulates apoptosis in vivo after DNA damage in...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2009-09, Vol.137 (3), p.945-954
Hauptverfasser:	Haegebarth, Andrea, Perekatt, Ansu O, Bie, Wenjun, Gierut, Jessica J, Tyner, Angela L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Apoptosis - radiation effects Caspase 3 - metabolism Cell Proliferation Cell Survival DNA Damage - physiology DNA Damage - radiation effects Enzyme Activation Gamma Rays Gastroenterology and Hepatology Immunohistochemistry In Situ Nick-End Labeling Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Intestinal Mucosa - radiation effects Male Mice Mice, Knockout Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Protein-Tyrosine Kinases Proto-Oncogene Proteins c-akt - metabolism Signal Transduction src-Family Kinases - metabolism src-Family Kinases - physiology
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