Differential expression of IL-17A and IL-17F is coupled to TCR signaling via Itk-mediated regulation of NFATc1

Th17 cells play major roles in autoimmunity and bacterial infections, yet how T cell receptor (TCR) signaling affects Th17 differentiation is relatively unknown. We demonstrate that CD4 + T cells deficient in Itk, a tyrosine kinase required for full TCR-induced activation of PLC-γ, exhibit decreased...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2009-10, Vol.31 (4), p.587-597
Hauptverfasser:	Gomez-Rodriguez, Julio, Sahu, Nisebita, Handon, Robin, Davidson, Todd S., Anderson, Stacie M., Kirby, Martha R., August, Avery, Schwartzberg, Pamela L.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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