Site-Specific DNA Structural and Dynamic Features Revealed by Nucleotide-Independent Nitroxide Probes

In site-directed spin labeling, a covalently attached nitroxide probe containing a chemically inert unpaired electron is utilized to obtain information on the local environment of the parent macromolecule. Studies presented here examine the feasibility of probing local DNA structural and dynamic fea...

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Veröffentlicht in:	Biochemistry (Easton) 2009-09, Vol.48 (36), p.8540-8550
Hauptverfasser:	Popova, Anna M, Kálai, Tamás, Hideg, Kálmán, Qin, Peter Z
Format:	Artikel
Sprache:	eng
Schlagworte:	BASIC BIOLOGICAL SCIENCES DNA DNA Probes - chemistry DNA Probes - metabolism ELECTRON SPIN RESONANCE ELECTRONS Environmental Molecular Sciences Laboratory Free Radicals - chemistry Free Radicals - metabolism GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE Nitrogen Oxides - chemistry Nitrogen Oxides - metabolism Nucleic Acid Conformation Nucleic Acid Heteroduplexes - chemistry Nucleic Acid Heteroduplexes - metabolism NUCLEIC ACIDS NUCLEOTIDES Phosphorothioate Oligonucleotides - chemistry Phosphorothioate Oligonucleotides - metabolism PROBES SPECTRA Spectrometry, Mass, Electrospray Ionization SPIN Spin Labels Stereoisomerism Structure-Activity Relationship Thermodynamics
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