Phospholamban Modulates the Functional Coupling between Nucleotide Domains in Ca-ATPase Oligomeric Complexes in Cardiac Sarcoplasmic Reticulum

Oligomeric interactions between Ca-ATPase polypeptide chains and their modulation by phospholamban (PLB) were measured in native cardiac sarcoplasmic reticulum (SR) microsomes. Progressive modification of Lys514 with fluorescein 5-isothiocyanate (FITC), which physically blocks access to the nucleoti...

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Veröffentlicht in:	Biochemistry (Easton) 2009-03, Vol.48 (11), p.2411-2421
Hauptverfasser:	Chen, Linda T. L, Yao, Qing, Soares, Thereza A, Squier, Thomas C, Bigelow, Diana J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP-ASE BASIC BIOLOGICAL SCIENCES BIOLOGICAL FUNCTIONS biomarkers Calcium - metabolism CALCIUM COMPLEXES Calcium-Binding Proteins - chemistry Calcium-Binding Proteins - metabolism CATALYSIS Cells, Cultured ENZYME ACTIVITY HEART Kinetics MICROSOMES Microsomes - chemistry Microsomes - metabolism MORPHOLOGICAL CHANGES MS Myocardium - chemistry Myocardium - metabolism nitrotyrosine NUCLEOTIDES Nucleotides - chemistry Nucleotides - metabolism ORGANIC PHOSPHORUS COMPOUNDS oxidation PHOSPHORYLATION POLYPEPTIDES Protein Binding Protein Structure, Tertiary proteomics SARCOPLASMIC RETICULUM Sarcoplasmic Reticulum - chemistry Sarcoplasmic Reticulum - metabolism Sarcoplasmic Reticulum Calcium-Transporting ATPases - chemistry Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism Swine
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