Mammalian Pitrilysin: Substrate Specificity and Mitochondrial Targeting

The substrate specificity of the mitochondrial metallopeptidase proteinase 1 (MP1) was investigated and its mitochondrial targeting signal identified. The substrate specificity of MP1 was examined with physiological peptides as substrates. Although the enzyme exhibits broad substrate specificity, th...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemistry (Easton) 2009-04, Vol.48 (13), p.2868-2877
Hauptverfasser:	Chow, K. Martin, Gakh, O, Payne, I. C, Juliano, Maria Aparecida, Juliano, Luiz, Isaya, G, Hersh, Louis B
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Amino Acid Sequence Animals beta-Endorphin - metabolism Cell Line Chromatography, High Pressure Liquid Citrate (si)-Synthase - metabolism Green Fluorescent Proteins - metabolism Humans Hydrolysis - drug effects Ions Kinetics Metalloendopeptidases - chemistry Metalloendopeptidases - metabolism Metals - pharmacology Mitochondria - drug effects Mitochondria - enzymology Molecular Sequence Data Protein Transport - drug effects Recombinant Fusion Proteins - metabolism Subcellular Fractions - drug effects Subcellular Fractions - enzymology Substrate Specificity - drug effects Tyrosine - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!