Divergence of macrophage phagocytic and antimicrobial programs in leprosy

Effective innate immunity against many microbial pathogens requires macrophage programs that upregulate phagocytosis and direct antimicrobial pathways, two functions generally assumed to be coordinately regulated. We investigated the regulation of these key functions in human blood-derived macrophag...

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Veröffentlicht in:	Cell host & microbe 2009-10, Vol.6 (4), p.343-353
Hauptverfasser:	Montoya, Dennis, Cruz, Daniel, Teles, Rosane M B, Lee, Delphine J, Ochoa, Maria Teresa, Krutzik, Stephan R, Chun, Rene, Schenk, Mirjam, Zhang, Xiaoran, Ferguson, Benjamin G, Burdick, Anne E, Sarno, Euzenir N, Rea, Thomas H, Hewison, Martin, Adams, John S, Cheng, Genhong, Modlin, Robert L
Format:	Artikel
Sprache:	eng
Schlagworte:	Gene Expression Profiling Gene Expression Regulation Humans Interleukin-10 - immunology Interleukin-15 - immunology Leprosy - immunology Macrophages - immunology Microbial Viability Mycobacterium leprae - immunology Mycobacterium leprae - physiology Phagocytosis
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