PMA induces expression from the herpes simplex virus thymidine kinase promoter via the activation of JNK and ERK in the presence of adenoviral E1A proteins

The herpes simplex virus type 1 (HSV-1) thymidine kinase (TK) promoter contains elements involved in both constitutive and induced expression. We determined that phorbol 12-myristate 13-acetate (PMA) induces the HSV-1 TK promoter in HEK293 cells. However, PMA did not induce expression from the promo...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2009-10, Vol.490 (2), p.145-157
Hauptverfasser:	Shifera, Amde Selassie, Hardin, John A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenovirus E1A Proteins - metabolism Base Sequence Cell Line DNA Primers - genetics E1A Enzyme Activation - drug effects ERK Gene Expression - drug effects Genes, Reporter Genes, Viral HeLa Cells Herpes simplex virus 1 Herpesvirus 1, Human - enzymology Herpesvirus 1, Human - genetics Humans JNK JNK Mitogen-Activated Protein Kinases - metabolism Luciferases, Renilla - genetics MAP Kinase Signaling System - drug effects Mitogen-Activated Protein Kinase Kinases - metabolism Models, Biological PMA Promoter Regions, Genetic - drug effects RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction - drug effects Tetradecanoylphorbol Acetate - pharmacology Thymidine kinase Thymidine Kinase - genetics
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