Poor outcome in chronic schizophrenia is associated with progressive loss of volume of the putamen
Abstract Background We have previously demonstrated that putaminal but not caudate volumes are associated with poor outcome in patients with chronic schizophrenia. Present longitudinal study was designed to investigate progressive differences in striatal volumes among chronic schizophrenia patients...
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| Veröffentlicht in: | Schizophrenia research 2009-09, Vol.113 (2), p.241-245 |
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| creator | Mitelman, Serge A Canfield, Emily L Chu, King-Wai Brickman, Adam M Shihabuddin, Lina Hazlett, Erin A Buchsbaum, Monte S |
| description | Abstract Background We have previously demonstrated that putaminal but not caudate volumes are associated with poor outcome in patients with chronic schizophrenia. Present longitudinal study was designed to investigate progressive differences in striatal volumes among chronic schizophrenia patients with different outcomes and healthy subjects. Methods Structural MRI scans were acquired at baseline and at follow-up four years later to evaluate volumetric changes in 26 poor-outcome schizophrenia patients, 23 good-outcome patients and 16 healthy subjects. Results Schizophrenia patients with different outcomes entered the study with similar volumes of the caudate nucleus and putamen. The rate of decline in volumes of the putamen was greater in patients with poor outcome than in the good-outcome group, so that their putaminal but not caudate volumes were significantly smaller at the time of follow-up. There were no differences in baseline and follow-up volumes of the putamen or in the rate of their progression among patients with schizophrenia and healthy comparison subjects. The caudate volumes were lower in schizophrenia patients than healthy subjects at baseline and follow-up, but showed no differential patterns of progression between the groups. Conclusions Volumes of the putamen may represent a longitudinal marker of treatment responsiveness and outcome in patients with chronic schizophrenia. |
| doi_str_mv | 10.1016/j.schres.2009.06.022 |
| format | Article |
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Present longitudinal study was designed to investigate progressive differences in striatal volumes among chronic schizophrenia patients with different outcomes and healthy subjects. Methods Structural MRI scans were acquired at baseline and at follow-up four years later to evaluate volumetric changes in 26 poor-outcome schizophrenia patients, 23 good-outcome patients and 16 healthy subjects. Results Schizophrenia patients with different outcomes entered the study with similar volumes of the caudate nucleus and putamen. The rate of decline in volumes of the putamen was greater in patients with poor outcome than in the good-outcome group, so that their putaminal but not caudate volumes were significantly smaller at the time of follow-up. There were no differences in baseline and follow-up volumes of the putamen or in the rate of their progression among patients with schizophrenia and healthy comparison subjects. The caudate volumes were lower in schizophrenia patients than healthy subjects at baseline and follow-up, but showed no differential patterns of progression between the groups. Conclusions Volumes of the putamen may represent a longitudinal marker of treatment responsiveness and outcome in patients with chronic schizophrenia.</description><identifier>ISSN: 0920-9964</identifier><identifier>EISSN: 1573-2509</identifier><identifier>DOI: 10.1016/j.schres.2009.06.022</identifier><identifier>PMID: 19616411</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adult ; Adult and adolescent clinical studies ; Analysis of Variance ; Biological and medical sciences ; Caudate nucleus ; Caudate Nucleus - pathology ; Chronic Disease ; Chronic schizophrenia ; Disease Progression ; Female ; Functional Laterality ; Humans ; Kraepelinian ; Longitudinal Studies ; Magnetic Resonance Imaging - methods ; Male ; Medical sciences ; Middle Aged ; Poor outcome ; Psychiatric Status Rating Scales ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Putamen ; Putamen - pathology ; Reference Values ; Schizophrenia ; Schizophrenia - pathology ; Severity of Illness Index ; Striatum</subject><ispartof>Schizophrenia research, 2009-09, Vol.113 (2), p.241-245</ispartof><rights>Elsevier B.V.</rights><rights>2009 Elsevier B.V.</rights><rights>2009 INIST-CNRS</rights><rights>2009 Elsevier B.V. All rights reserved 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c546t-7ec5fd918439b0ba216e50668ba16c90975f7ea234a6df7a8afa4529eea784e53</citedby><cites>FETCH-LOGICAL-c546t-7ec5fd918439b0ba216e50668ba16c90975f7ea234a6df7a8afa4529eea784e53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.schres.2009.06.022$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21893781$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19616411$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mitelman, Serge A</creatorcontrib><creatorcontrib>Canfield, Emily L</creatorcontrib><creatorcontrib>Chu, King-Wai</creatorcontrib><creatorcontrib>Brickman, Adam M</creatorcontrib><creatorcontrib>Shihabuddin, Lina</creatorcontrib><creatorcontrib>Hazlett, Erin A</creatorcontrib><creatorcontrib>Buchsbaum, Monte S</creatorcontrib><title>Poor outcome in chronic schizophrenia is associated with progressive loss of volume of the putamen</title><title>Schizophrenia research</title><addtitle>Schizophr Res</addtitle><description>Abstract Background We have previously demonstrated that putaminal but not caudate volumes are associated with poor outcome in patients with chronic schizophrenia. Present longitudinal study was designed to investigate progressive differences in striatal volumes among chronic schizophrenia patients with different outcomes and healthy subjects. Methods Structural MRI scans were acquired at baseline and at follow-up four years later to evaluate volumetric changes in 26 poor-outcome schizophrenia patients, 23 good-outcome patients and 16 healthy subjects. Results Schizophrenia patients with different outcomes entered the study with similar volumes of the caudate nucleus and putamen. The rate of decline in volumes of the putamen was greater in patients with poor outcome than in the good-outcome group, so that their putaminal but not caudate volumes were significantly smaller at the time of follow-up. There were no differences in baseline and follow-up volumes of the putamen or in the rate of their progression among patients with schizophrenia and healthy comparison subjects. The caudate volumes were lower in schizophrenia patients than healthy subjects at baseline and follow-up, but showed no differential patterns of progression between the groups. Conclusions Volumes of the putamen may represent a longitudinal marker of treatment responsiveness and outcome in patients with chronic schizophrenia.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Caudate nucleus</subject><subject>Caudate Nucleus - pathology</subject><subject>Chronic Disease</subject><subject>Chronic schizophrenia</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Functional Laterality</subject><subject>Humans</subject><subject>Kraepelinian</subject><subject>Longitudinal Studies</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Poor outcome</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Putamen</subject><subject>Putamen - pathology</subject><subject>Reference Values</subject><subject>Schizophrenia</subject><subject>Schizophrenia - pathology</subject><subject>Severity of Illness Index</subject><subject>Striatum</subject><issn>0920-9964</issn><issn>1573-2509</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk9v1DAQxSMEotvCN0DIF7gljJ3YiS9IqCp_pEogAWdr4ky6XpI42MlW5dPj1a5a4MLJlvzmvRn_JstecCg4cPVmV0S7DRQLAaALUAUI8SjbcFmXuZCgH2cb0AJyrVV1lp3HuAMALqF-mp1xrbiqON9k7RfvA_PrYv1IzE0sefrJWZbM3S8_p4TJIXORYYzeOlyoY7du2bI5-JsUH92e2OBjZL5nez-sySbdli2xeV1wpOlZ9qTHIdLz03mRfX9_9e3yY379-cOny3fXuZWVWvKarOw7zZuq1C20KLgiCUo1LXJlNeha9jWhKCtUXV9jgz1WUmgirJuKZHmRvT36zms7UmdpWgIOZg5uxHBnPDrz98vktubG742oVVkJSAavTwbB_1wpLmZ00dIw4ER-jUbVspGl4klYHYU2pMED9fchHMwBjtmZIxxzgGNAmQQnlb38s8GHohONJHh1EmC0OPQBJ-vivU7wRpd1wx8mpfSde0chpTmaLHUukF1M593_OvnXwA4uUcfhB91R3Pk1TAmV4SYKA-brYZEOewQaQGjRlL8B7yvHQw</recordid><startdate>20090901</startdate><enddate>20090901</enddate><creator>Mitelman, Serge A</creator><creator>Canfield, Emily L</creator><creator>Chu, King-Wai</creator><creator>Brickman, Adam M</creator><creator>Shihabuddin, Lina</creator><creator>Hazlett, Erin A</creator><creator>Buchsbaum, Monte S</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090901</creationdate><title>Poor outcome in chronic schizophrenia is associated with progressive loss of volume of the putamen</title><author>Mitelman, Serge A ; Canfield, Emily L ; Chu, King-Wai ; Brickman, Adam M ; Shihabuddin, Lina ; Hazlett, Erin A ; Buchsbaum, Monte S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c546t-7ec5fd918439b0ba216e50668ba16c90975f7ea234a6df7a8afa4529eea784e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Caudate nucleus</topic><topic>Caudate Nucleus - pathology</topic><topic>Chronic Disease</topic><topic>Chronic schizophrenia</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Functional Laterality</topic><topic>Humans</topic><topic>Kraepelinian</topic><topic>Longitudinal Studies</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Poor outcome</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Putamen</topic><topic>Putamen - pathology</topic><topic>Reference Values</topic><topic>Schizophrenia</topic><topic>Schizophrenia - pathology</topic><topic>Severity of Illness Index</topic><topic>Striatum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mitelman, Serge A</creatorcontrib><creatorcontrib>Canfield, Emily L</creatorcontrib><creatorcontrib>Chu, King-Wai</creatorcontrib><creatorcontrib>Brickman, Adam M</creatorcontrib><creatorcontrib>Shihabuddin, Lina</creatorcontrib><creatorcontrib>Hazlett, Erin A</creatorcontrib><creatorcontrib>Buchsbaum, Monte S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Schizophrenia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mitelman, Serge A</au><au>Canfield, Emily L</au><au>Chu, King-Wai</au><au>Brickman, Adam M</au><au>Shihabuddin, Lina</au><au>Hazlett, Erin A</au><au>Buchsbaum, Monte S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Poor outcome in chronic schizophrenia is associated with progressive loss of volume of the putamen</atitle><jtitle>Schizophrenia research</jtitle><addtitle>Schizophr Res</addtitle><date>2009-09-01</date><risdate>2009</risdate><volume>113</volume><issue>2</issue><spage>241</spage><epage>245</epage><pages>241-245</pages><issn>0920-9964</issn><eissn>1573-2509</eissn><abstract>Abstract Background We have previously demonstrated that putaminal but not caudate volumes are associated with poor outcome in patients with chronic schizophrenia. Present longitudinal study was designed to investigate progressive differences in striatal volumes among chronic schizophrenia patients with different outcomes and healthy subjects. Methods Structural MRI scans were acquired at baseline and at follow-up four years later to evaluate volumetric changes in 26 poor-outcome schizophrenia patients, 23 good-outcome patients and 16 healthy subjects. Results Schizophrenia patients with different outcomes entered the study with similar volumes of the caudate nucleus and putamen. The rate of decline in volumes of the putamen was greater in patients with poor outcome than in the good-outcome group, so that their putaminal but not caudate volumes were significantly smaller at the time of follow-up. There were no differences in baseline and follow-up volumes of the putamen or in the rate of their progression among patients with schizophrenia and healthy comparison subjects. The caudate volumes were lower in schizophrenia patients than healthy subjects at baseline and follow-up, but showed no differential patterns of progression between the groups. Conclusions Volumes of the putamen may represent a longitudinal marker of treatment responsiveness and outcome in patients with chronic schizophrenia.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>19616411</pmid><doi>10.1016/j.schres.2009.06.022</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Analysis of Variance Biological and medical sciences Caudate nucleus Caudate Nucleus - pathology Chronic Disease Chronic schizophrenia Disease Progression Female Functional Laterality Humans Kraepelinian Longitudinal Studies Magnetic Resonance Imaging - methods Male Medical sciences Middle Aged Poor outcome Psychiatric Status Rating Scales Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Putamen Putamen - pathology Reference Values Schizophrenia Schizophrenia - pathology Severity of Illness Index Striatum |
| title | Poor outcome in chronic schizophrenia is associated with progressive loss of volume of the putamen |
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