Acute seizure activity promotes lipid peroxidation, increased nitrite levels and adaptive pathways against oxidative stress in the frontal cortex and striatum

Previous experiments have shown that the generation of free radicals in rat brain homogenates is increased following pilocarpine-induced seizures and status epilepticus (SE). This study was aimed at investigating the changes in neurochemical mechanisms such as lipid peroxidation levels, nitrite cont...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2009-07, Vol.2 (3), p.130-137
Hauptverfasser:	Júnior, Hélio Vitoriano Nobre, de França Fonteles, Marta Maria, Mendes de Freitas, Rivelilson
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Catalase - metabolism Corpus Striatum - drug effects Corpus Striatum - metabolism Frontal Lobe - drug effects Frontal Lobe - metabolism Glutathione - metabolism Lipid Peroxidation Nitrites - metabolism Oxidative Stress Pilocarpine - toxicity Rats Rats, Wistar Research Papers Seizures - chemically induced Seizures - metabolism Status Epilepticus - chemically induced Status Epilepticus - metabolism Superoxide Dismutase - metabolism
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