RNA Dimerization Promotes PKR Dimerization and Activation

The double-stranded RNA (dsRNA)-activated protein kinase [protein kinase R (PKR)] plays a major role in the innate immune response in humans. PKR binds dsRNA non-sequence specifically and requires a minimum of 15-bp dsRNA for one protein to bind and 30-bp dsRNA to induce protein dimerization and act...

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Veröffentlicht in:	Journal of molecular biology 2009-07, Vol.390 (2), p.319-338
Hauptverfasser:	Heinicke, Laurie A., Wong, C. Jason, Lary, Jeffrey, Nallagatla, Subba Rao, Diegelman-Parente, Amy, Zheng, Xiaofeng, Cole, James L., Bevilacqua, Philip C.
Format:	Artikel
Sprache:	eng
Schlagworte:	analytical ultracentrifugation Base Sequence Dimerization eIF-2 Kinase - metabolism HIV Long Terminal Repeat - genetics HIV-1 - genetics Human immunodeficiency virus 1 Humans innate immunity Models, Biological Models, Molecular Molecular Sequence Data Nucleic Acid Conformation Protein Binding protein kinase RNA folding RNA, Double-Stranded - metabolism RNA, Viral - genetics RNA, Viral - metabolism RNA–protein interaction
Online-Zugang:	Volltext
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