Association studies of erythoid α‐spectrin at the tetramerization site

Summary The functional roles of residues 21–43 and 55–59 in the α‐spectrin N‐terminal region in forming tetramers were determined by the introduction of mutations at each of these positions. We measured association affinities for tetramer formation (Kd), which can be used to predict clinical severit...

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Veröffentlicht in:	British journal of haematology 2009-11, Vol.147 (3), p.392-395
Hauptverfasser:	Lam, Vinh Q., Antoniou, Chloe, Rolius, Ramunas, Fung, Leslie W.‐M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemias. Hemoglobinopathies Biological and medical sciences Diseases of red blood cells Hematologic and hematopoietic diseases hereditary elliptocytosis hereditary pyropoikilocytosis Medical sciences protein‐protein interactions spectrin tetramer
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