Ect2 links the PKCι-Par6α complex to Rac1 activation and cellular transformation

Protein kinase Cι (PKCι) promotes non-small cell lung cancer (NSCLC) by binding to Par6α and activating a Rac1-Pak-Mek1,2-Erk1,2 signaling cascade. The mechanism by which the PKCι–Par6α complex regulates Rac1 is unknown. Here we show that epithelial cell transforming sequence 2 (Ect2), a guanine nuc...

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Veröffentlicht in:	Oncogene 2009-10, Vol.28 (41), p.3597-3607
Hauptverfasser:	Justilien, V, Fields, A P
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cell Biology Cell proliferation Cytokinesis Cytoplasm Epithelial cells Extracellular signal-regulated kinase Genetic transformation Guanine Guanine nucleotide exchange factor Human Genetics Internal Medicine Kinases Localization Lung cancer Medicine Medicine & Public Health Non-small cell lung carcinoma Oncology original-article Protein kinase Protein kinase C Rac1 protein RNA-mediated interference Small cell lung carcinoma Tumorigenicity Tumors
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