Systems Biology Modeling of the Radiation Sensitivity Network: A Biomarker Discovery Platform

Purpose The discovery of effective biomarkers is a fundamental goal of molecular medicine. Developing a systems–biology understanding of radiosensitivity can enhance our ability of identifying radiation-specific biomarkers. Methods and Materials Radiosensitivity, as represented by the survival fract...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2009-10, Vol.75 (2), p.497-505
Hauptverfasser:	Eschrich, Steven, Ph.D, Zhang, Hongling, Ph.D, Zhao, Haiyan, B.S, Boulware, David, M.S, Lee, Ji-Hyun, Dr.Ph, Bloom, Gregory, Ph.D, Torres-Roca, Javier F., M.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms ANIMAL CELLS APOPTOSIS BIOLOGICAL MARKERS BIOLOGICAL PATHWAYS BIOLOGY CELL CYCLE Cell Line, Tumor - pathology Cell Line, Tumor - radiation effects Cell Survival - genetics Cell Survival - radiation effects Cluster Analysis Databases, Factual DNA REPAIR DRUGS gene expression Gene Expression - genetics Gene Expression Profiling - methods Gene Knockdown Techniques - methods Gene Regulatory Networks - genetics GENES Genes, jun - genetics Genes, p53 - genetics Genes, ras - genetics Genetic Markers Hematology, Oncology and Palliative Medicine Humans LARGE INTESTINE Linear Models linear regression LUNGS MAMMARY GLANDS mathematical modeling METABOLISM Models, Genetic NEOPLASMS Radiation Dosage Radiation Tolerance - genetics Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOSENSITIVITY REGRESSION ANALYSIS SIMULATION SURVIVAL CURVES systems biology
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