Western-Style Diets Induce Oxidative Stress and Dysregulate Immune Responses in the Colon in a Mouse Model of Sporadic Colon Cancer

A Western-style diet (WD), defined by high-fat, low-calcium, and vitamin D content, is associated with increased risk of human colorectal cancer. Understanding molecular mechanisms altered by the WD is crucial to develop preventive and therapeutic strategies. Effects of a WD on the colonic transcrip...

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Veröffentlicht in:	The Journal of nutrition 2009-11, Vol.139 (11), p.2072-2078
Hauptverfasser:	Erdelyi, Ildiko, Levenkova, Natasha, Lin, Elaine Y, Pinto, John T, Lipkin, Martin, Quimby, Fred W, Holt, Peter R
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models Animals biochemical pathways calcium colon Colonic Neoplasms - etiology colorectal neoplasms Colorectal Neoplasms - epidemiology Colorectal Neoplasms - etiology diet Diet - adverse effects dietary fat dietary minerals Disease Models, Animal gene expression Gene Expression Profiling Gene Expression Regulation - drug effects glutathione Homeostasis - drug effects Humans immune response Immunity - drug effects lipid metabolism macrophages Male metabolism Mice Mice, Inbred C57BL Nutrition and Disease Oligonucleotide Array Sequence Analysis oxidative stress Oxidative Stress - physiology protein synthesis Reverse Transcriptase Polymerase Chain Reaction RNA - genetics RNA - isolation & purification Transcription, Genetic - drug effects transcriptome transcriptomics vitamin D Weight Gain xenobiotics
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