In-vitro Relationship between Protein-binding and Free Drug Concentrations of a Water-soluble Selective Beta-adrenoreceptor Antagonist (Atenolol) and Its Interaction with Arsenic
The degree of binding of a drug to plasma proteins has a marked effect on its distribution, elimination, and pharmacological effect since only the unbound fraction is available for distribution into extra-vascular space. The protein-binding of atenolol was measured by equilibrium dialysis in the bov...
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| Veröffentlicht in: | Journal of health, population and nutrition population and nutrition, 2009-02, Vol.27 (1), p.20-30 |
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| creator | Alam, M.A Awal, M.A Subhan, N Mostofa, M |
| description | The degree of binding of a drug to plasma proteins has a marked effect
on its distribution, elimination, and pharmacological effect since only
the unbound fraction is available for distribution into extra-vascular
space. The protein-binding of atenolol was measured by equilibrium
dialysis in the bovine serum albumin (BSA). Free atenolol concentration
was increased due to addition of arsenic which reduced the binding of
the compounds to BSA. During concurrent administration, arsenic
displaced atenolol from its high-affini-ty binding Site I, and free
concentration of atenolol increased from 4.286±0.629% and
5.953±0.605% to 82.153±1.924% and 85.486±1.158% in
absence and presence of Site I probe respectively. Thus, it can be
suggested that arsenic displaced atenolol from its binding site
resulting in an increase of the free atenolol concentration in plasma. |
| doi_str_mv | 10.3329/jhpn.v27i1.3315 |
| format | Article |
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on its distribution, elimination, and pharmacological effect since only
the unbound fraction is available for distribution into extra-vascular
space. The protein-binding of atenolol was measured by equilibrium
dialysis in the bovine serum albumin (BSA). Free atenolol concentration
was increased due to addition of arsenic which reduced the binding of
the compounds to BSA. During concurrent administration, arsenic
displaced atenolol from its high-affini-ty binding Site I, and free
concentration of atenolol increased from 4.286±0.629% and
5.953±0.605% to 82.153±1.924% and 85.486±1.158% in
absence and presence of Site I probe respectively. Thus, it can be
suggested that arsenic displaced atenolol from its binding site
resulting in an increase of the free atenolol concentration in plasma.</description><identifier>ISSN: 1606-0997</identifier><identifier>EISSN: 2072-1315</identifier><identifier>DOI: 10.3329/jhpn.v27i1.3315</identifier><identifier>PMID: 19248645</identifier><language>eng</language><publisher>Bangladesh: icddr,b</publisher><subject>Adrenergic beta-Antagonists - chemistry ; Adrenergic beta-Antagonists - pharmacokinetics ; Albumins ; Animals ; Antagonist drugs ; Arsenic ; Arsenic - chemistry ; Arsenic - pharmacokinetics ; Atenolol ; Atenolol - chemistry ; Atenolol - pharmacokinetics ; Binding Sites ; Binding, Competitive ; Biological Availability ; Blood proteins ; Bovine serum albumin ; Cattle ; Concentration ; Dialysis ; Drug Interactions ; Elimination ; Humans ; Hypertension ; Original Papers ; Pharmacokinetics ; Pharmacology ; Physiological aspects ; Plasma ; Plasma protein-binding ; Protein binding ; Proteins ; Serum ; Serum Albumin - chemistry ; Serum Albumin - pharmacokinetics ; Serum albumins ; Sodium ; Ungulates</subject><ispartof>Journal of health, population and nutrition, 2009-02, Vol.27 (1), p.20-30</ispartof><rights>Copyright 2009 - International Centre For Diarrhoeal Disease Research, Bangladesh</rights><rights>Copyright © 2009 International Centre for Diarrhoeal Disease Research</rights><rights>COPYRIGHT 2009 BioMed Central Ltd.</rights><rights>Copyright Intenational Centre for Diarrhoeal Disease Research, Bangladesh Feb 2009</rights><rights>INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH, BANGLADESH 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b633t-36a8fd78ee5968cc603a0e57425611fe6bab9ef60d4a26653be12a056c2527dd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/23499733$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/23499733$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,315,728,781,785,804,886,12851,27929,27930,31004,31005,53796,53798,58022,58255,79431</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19248645$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alam, M.A</creatorcontrib><creatorcontrib>Awal, M.A</creatorcontrib><creatorcontrib>Subhan, N</creatorcontrib><creatorcontrib>Mostofa, M</creatorcontrib><title>In-vitro Relationship between Protein-binding and Free Drug Concentrations of a Water-soluble Selective Beta-adrenoreceptor Antagonist (Atenolol) and Its Interaction with Arsenic</title><title>Journal of health, population and nutrition</title><addtitle>J Health Popul Nutr</addtitle><description>The degree of binding of a drug to plasma proteins has a marked effect
on its distribution, elimination, and pharmacological effect since only
the unbound fraction is available for distribution into extra-vascular
space. The protein-binding of atenolol was measured by equilibrium
dialysis in the bovine serum albumin (BSA). Free atenolol concentration
was increased due to addition of arsenic which reduced the binding of
the compounds to BSA. During concurrent administration, arsenic
displaced atenolol from its high-affini-ty binding Site I, and free
concentration of atenolol increased from 4.286±0.629% and
5.953±0.605% to 82.153±1.924% and 85.486±1.158% in
absence and presence of Site I probe respectively. Thus, it can be
suggested that arsenic displaced atenolol from its binding site
resulting in an increase of the free atenolol concentration in plasma.</description><subject>Adrenergic beta-Antagonists - chemistry</subject><subject>Adrenergic beta-Antagonists - pharmacokinetics</subject><subject>Albumins</subject><subject>Animals</subject><subject>Antagonist drugs</subject><subject>Arsenic</subject><subject>Arsenic - chemistry</subject><subject>Arsenic - pharmacokinetics</subject><subject>Atenolol</subject><subject>Atenolol - chemistry</subject><subject>Atenolol - pharmacokinetics</subject><subject>Binding Sites</subject><subject>Binding, Competitive</subject><subject>Biological Availability</subject><subject>Blood proteins</subject><subject>Bovine serum albumin</subject><subject>Cattle</subject><subject>Concentration</subject><subject>Dialysis</subject><subject>Drug Interactions</subject><subject>Elimination</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Original Papers</subject><subject>Pharmacokinetics</subject><subject>Pharmacology</subject><subject>Physiological aspects</subject><subject>Plasma</subject><subject>Plasma protein-binding</subject><subject>Protein binding</subject><subject>Proteins</subject><subject>Serum</subject><subject>Serum Albumin - chemistry</subject><subject>Serum Albumin - pharmacokinetics</subject><subject>Serum albumins</subject><subject>Sodium</subject><subject>Ungulates</subject><issn>1606-0997</issn><issn>2072-1315</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9k11v0zAUhiMEYmNwzRXIGtJgF9n8kTjJDVIpDCpNAm0gLi3HOWlcuXaxnQ7-Fr8Qdx1jRQjFUmyf57z2sV9n2VOCTxijzeliWNmTNa00SWNS3sv2Ka5oTlL_frZPOOY5bppqL3sUwgJj2uCaPsz2SEOLmhflfvZzZvO1jt6hCzAyamfDoFeohXgFYNEn7yJom7fadtrOkbQdOvMA6K0f52jqrAIb_TYPuR5J9FVG8HlwZmwNoEswoKJeA3oDUeay82CdBwWr6Dya2CjnzuoQ0atJTBHjzPH1GrMY0MwmJak22uhKxwFNfACr1ePsQS9NgCc3_4Psy9m7z9MP-fnH97Pp5DxvOWMxZ1zWfVfVAGXDa6U4ZhJDWRW05IT0wFvZNtBz3BWScl6yFgiVuOSKlrTqOnaQvd7qrsZ2Cd22UiNWXi-l_yGc1GI3YvUg5m4taMVJjcsk8PJGwLtvI4QoljooMEZacGMQNaVFUxV1k8ij_5IUl4RhThN4-Be4cKO36RgSQ5smVY4T9GILzaUBoW3v0vbURlFMElVhTgqWqJN_UOnrYKmVs9DrNL-TcLyTkJgI3-NcjiGI2eXFLnt0hx1AmjhsPHFtlF3wdAsq70Lw0N-eL8FiY3Gxsbi4trjYWDxlPL97LX_4G08n4NkWWIRksts4ZUV6CexO4a12Rlu4JZTXUvyeHGxquMG4YL8AkVYTyQ</recordid><startdate>20090201</startdate><enddate>20090201</enddate><creator>Alam, M.A</creator><creator>Awal, M.A</creator><creator>Subhan, N</creator><creator>Mostofa, M</creator><general>icddr,b</general><general>ICDDR,B: Centre for Health and Population Research</general><general>BioMed Central Ltd</general><general>BioMed Central</general><general>International Centre for Diarrhoeal Disease Research, Bangladesh</general><scope>RBI</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>0-V</scope><scope>3V.</scope><scope>7QJ</scope><scope>7QL</scope><scope>7RQ</scope><scope>7RV</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>88J</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2R</scope><scope>M2S</scope><scope>M7N</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7U7</scope><scope>5PM</scope></search><sort><creationdate>20090201</creationdate><title>In-vitro Relationship between Protein-binding and Free Drug Concentrations of a Water-soluble Selective Beta-adrenoreceptor Antagonist (Atenolol) and Its Interaction with Arsenic</title><author>Alam, M.A ; Awal, M.A ; Subhan, N ; Mostofa, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b633t-36a8fd78ee5968cc603a0e57425611fe6bab9ef60d4a26653be12a056c2527dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adrenergic beta-Antagonists - chemistry</topic><topic>Adrenergic beta-Antagonists - pharmacokinetics</topic><topic>Albumins</topic><topic>Animals</topic><topic>Antagonist drugs</topic><topic>Arsenic</topic><topic>Arsenic - chemistry</topic><topic>Arsenic - pharmacokinetics</topic><topic>Atenolol</topic><topic>Atenolol - chemistry</topic><topic>Atenolol - pharmacokinetics</topic><topic>Binding Sites</topic><topic>Binding, Competitive</topic><topic>Biological Availability</topic><topic>Blood proteins</topic><topic>Bovine serum albumin</topic><topic>Cattle</topic><topic>Concentration</topic><topic>Dialysis</topic><topic>Drug Interactions</topic><topic>Elimination</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Original Papers</topic><topic>Pharmacokinetics</topic><topic>Pharmacology</topic><topic>Physiological aspects</topic><topic>Plasma</topic><topic>Plasma protein-binding</topic><topic>Protein binding</topic><topic>Proteins</topic><topic>Serum</topic><topic>Serum Albumin - chemistry</topic><topic>Serum Albumin - pharmacokinetics</topic><topic>Serum albumins</topic><topic>Sodium</topic><topic>Ungulates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alam, M.A</creatorcontrib><creatorcontrib>Awal, M.A</creatorcontrib><creatorcontrib>Subhan, N</creatorcontrib><creatorcontrib>Mostofa, M</creatorcontrib><collection>Bioline International</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Career & Technical Education Database</collection><collection>Nursing & Allied Health Database</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Sociology Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Social Science Database</collection><collection>Sociology Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Toxicology Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of health, population and nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alam, M.A</au><au>Awal, M.A</au><au>Subhan, N</au><au>Mostofa, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In-vitro Relationship between Protein-binding and Free Drug Concentrations of a Water-soluble Selective Beta-adrenoreceptor Antagonist (Atenolol) and Its Interaction with Arsenic</atitle><jtitle>Journal of health, population and nutrition</jtitle><addtitle>J Health Popul Nutr</addtitle><date>2009-02-01</date><risdate>2009</risdate><volume>27</volume><issue>1</issue><spage>20</spage><epage>30</epage><pages>20-30</pages><issn>1606-0997</issn><eissn>2072-1315</eissn><abstract>The degree of binding of a drug to plasma proteins has a marked effect
on its distribution, elimination, and pharmacological effect since only
the unbound fraction is available for distribution into extra-vascular
space. The protein-binding of atenolol was measured by equilibrium
dialysis in the bovine serum albumin (BSA). Free atenolol concentration
was increased due to addition of arsenic which reduced the binding of
the compounds to BSA. During concurrent administration, arsenic
displaced atenolol from its high-affini-ty binding Site I, and free
concentration of atenolol increased from 4.286±0.629% and
5.953±0.605% to 82.153±1.924% and 85.486±1.158% in
absence and presence of Site I probe respectively. Thus, it can be
suggested that arsenic displaced atenolol from its binding site
resulting in an increase of the free atenolol concentration in plasma.</abstract><cop>Bangladesh</cop><pub>icddr,b</pub><pmid>19248645</pmid><doi>10.3329/jhpn.v27i1.3315</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of health, population and nutrition, 2009-02, Vol.27 (1), p.20-30 |
| issn | 1606-0997 2072-1315 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2761805 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Applied Social Sciences Index & Abstracts (ASSIA); JSTOR Archive Collection A-Z Listing; Bioline International; PubMed Central |
| subjects | Adrenergic beta-Antagonists - chemistry Adrenergic beta-Antagonists - pharmacokinetics Albumins Animals Antagonist drugs Arsenic Arsenic - chemistry Arsenic - pharmacokinetics Atenolol Atenolol - chemistry Atenolol - pharmacokinetics Binding Sites Binding, Competitive Biological Availability Blood proteins Bovine serum albumin Cattle Concentration Dialysis Drug Interactions Elimination Humans Hypertension Original Papers Pharmacokinetics Pharmacology Physiological aspects Plasma Plasma protein-binding Protein binding Proteins Serum Serum Albumin - chemistry Serum Albumin - pharmacokinetics Serum albumins Sodium Ungulates |
| title | In-vitro Relationship between Protein-binding and Free Drug Concentrations of a Water-soluble Selective Beta-adrenoreceptor Antagonist (Atenolol) and Its Interaction with Arsenic |
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