Determination of risperidone and enantiomers of 9-hydroxyrisperidone in plasma by LC-MS/MS

A robust and validated liquid–liquid extraction LC-MS/MS method was developed for population pharmacokinetic analysis and therapeutic drug monitoring of risperidone and the enantiomers of its major active metabolite (+)-and (−)9-hydroxyrisperidone in pediatric patients. The method was rapid, sensiti...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2007-06, Vol.852 (1), p.497-504
Hauptverfasser:	Čabovska, B., Cox, S.L., Vinks, A.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	9-Hydroxyrisperidone enantiomers Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Child Chromatography, Liquid - methods Fundamental and applied biological sciences. Psychology General pharmacology Humans Isoxazoles - blood LC-MS/MS method Matrix effects Medical sciences Paliperidone Palmitate Pharmacology. Drug treatments Pyrimidines - blood Reference Standards Reproducibility of Results Risperidone Risperidone - blood Sensitivity and Specificity Spectrometry, Mass, Electrospray Ionization - methods Stereoisomerism Tandem Mass Spectrometry - methods
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