Nano positioning system reveals the course of upstream and nontemplate DNA within the RNA polymerase II elongation complex

Crystallographic studies of the RNA polymerase II (Pol II) elongation complex (EC) revealed the locations of downstream DNA and the DNA-RNA hybrid, but not the course of the nontemplate DNA strand in the transcription bubble and the upstream DNA duplex. Here we used single-molecule Fluorescence Reso...

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Veröffentlicht in:	Nucleic acids research 2009-09, Vol.37 (17), p.5803-5809
Hauptverfasser:	Andrecka, Joanna, Treutlein, Barbara, Arcusa, Maria Angeles Izquierdo, Muschielok, Adam, Lewis, Robert, Cheung, Alan C.M, Cramer, Patrick, Michaelis, Jens
Format:	Artikel
Sprache:	eng
Schlagworte:	Bayes Theorem Crystallography, X-Ray DNA - chemistry Fluorescence Resonance Energy Transfer Models, Molecular Nucleic Acid Enzymes RNA - chemistry RNA Polymerase II - chemistry Templates, Genetic Transcription, Genetic
Online-Zugang:	Volltext
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