The Venus flytrap of periplasmic binding proteins: an ancient protein module present in multiple drug receptors

Located between the inner and outer membranes of Gram-negative bacteria, periplasmic binding proteins (PBPs) scavenge or sense diverse nutrients in the environment by coupling to transporters or chemotaxis receptors in the inner membrane. Their three-dimensional structures have been deduced in atomi...

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Veröffentlicht in:	AAPS PharmSci 1999-01, Vol.1 (2), p.E2-26
Hauptverfasser:	Felder, C B, Graul, R C, Lee, A Y, Merkle, H P, Sadee, W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Artificial Gene Fusion Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Carrier Proteins - chemistry Carrier Proteins - genetics Carrier Proteins - metabolism Crystallography, X-Ray Databases, Factual Escherichia coli Proteins Evolution, Molecular Gram-Negative Bacteria - chemistry Gram-Negative Bacteria - metabolism GTP-Binding Proteins - metabolism Lac Repressors Ligands Membrane Transport Proteins - genetics Models, Molecular Peptides - chemistry Protein Conformation Receptors, Drug - chemistry Receptors, Drug - genetics Receptors, Drug - metabolism Receptors, Glutamate - chemistry Receptors, Glutamate - metabolism Repressor Proteins - chemistry
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