Immunotoxins for targeted cancer therapy

Immunotoxins are proteins that contain a toxin along with an antibody or growth factor that binds specifically to target cells. Nearly all protein toxins work by enzymatically inhibiting protein synthesis. For the immunotoxin to work, it must bind to and be internalized by the target cells, and the...

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Bibliographische Detailangaben

Veröffentlicht in:	The AAPS journal 2006-08, Vol.8 (3), p.E532-E551
1. Verfasser:	Kreitman, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - administration & dosage Antineoplastic Agents - therapeutic use Bacterial Toxins - chemistry Clinical Trials as Topic Diphtheria Toxin - chemistry Drug Delivery Systems Humans Immunoglobulin Fragments - metabolism Immunotoxins - administration & dosage Immunotoxins - therapeutic use Interleukin-2 - chemistry Leukemia, Hairy Cell - drug therapy Recombinant Fusion Proteins - administration & dosage Recombinant Fusion Proteins - therapeutic use Sialic Acid Binding Ig-like Lectin 2 - chemistry
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