Immature and mature species of the human Prostacyclin Receptor are ubiquitinated and targeted to the 26S proteasomal or lysosomal degradation pathways, respectively

The human prostacyclin receptor (hIP) undergoes agonist-induced phosphorylation, desensitisation and internalisation and may be recycled to the plasma membrane or targeted for degradation by, as yet, unknown mechanism(s). Herein it was sought to investigate the turnover of the hIP under basal condit...

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Veröffentlicht in:	Journal of molecular signaling 2009-09, Vol.4 (1), p.7-7
Hauptverfasser:	Donnellan, Peter D, Kinsella, B Therese
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical research Kinases Ligands Medical research Molecular weight Phosphorylation Proteins Smooth muscle
Online-Zugang:	Volltext
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