Serum Calcium and Incident and Fatal Prostate Cancer in the National Health and Nutrition Examination Survey
We examined the association between serum calcium levels and the risk for prostate cancer using a prospective cohort, the National Health and Nutrition Examination Survey (NHANES) and the NHANES Epidemiologic Follow-up Study. Eighty-five incident cases of prostate cancer and 25 prostate cancer death...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2008-09, Vol.17 (9), p.2302-2305 |
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| creator | SKINNER, Halcyon G SCHWARTZ, Gary G |
| description | We examined the association between serum calcium levels and the risk for prostate cancer using a prospective cohort, the
National Health and Nutrition Examination Survey (NHANES) and the NHANES Epidemiologic Follow-up Study. Eighty-five incident
cases of prostate cancer and 25 prostate cancer deaths occurred over 46,188 person-years of follow-up. Serum calcium was determined
an average of 9.9 years before the diagnosis of prostate cancer. Comparing men in the top with men in the bottom tertile of
serum calcium, the multivariable-adjusted relative hazard for fatal prostate cancer was 2.68 (95% confidence interval, 1.02-6.99;
P trend = 0.04). For incident prostate cancer, the relative risk for the same comparison was 1.31 (95% confidence interval, 0.77-2.20;
P trend = 0.34). These results support the hypothesis that high serum calcium or a factor strongly associated with it (e.g., high
serum parathyroid hormone) increases the risk for fatal prostate cancer. Our finding of a >2.5-fold increased risk for men
in the highest tertile of serum calcium is comparable in magnitude with the risk associated with family history and could
add significantly to our ability to identify men at increased risk for fatal prostate cancer. (Cancer Epidemiol Biomarkers
Prev 2008;17(9):2302–5) |
| doi_str_mv | 10.1158/1055-9965.EPI-08-0365 |
| format | Article |
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National Health and Nutrition Examination Survey (NHANES) and the NHANES Epidemiologic Follow-up Study. Eighty-five incident
cases of prostate cancer and 25 prostate cancer deaths occurred over 46,188 person-years of follow-up. Serum calcium was determined
an average of 9.9 years before the diagnosis of prostate cancer. Comparing men in the top with men in the bottom tertile of
serum calcium, the multivariable-adjusted relative hazard for fatal prostate cancer was 2.68 (95% confidence interval, 1.02-6.99;
P trend = 0.04). For incident prostate cancer, the relative risk for the same comparison was 1.31 (95% confidence interval, 0.77-2.20;
P trend = 0.34). These results support the hypothesis that high serum calcium or a factor strongly associated with it (e.g., high
serum parathyroid hormone) increases the risk for fatal prostate cancer. Our finding of a >2.5-fold increased risk for men
in the highest tertile of serum calcium is comparable in magnitude with the risk associated with family history and could
add significantly to our ability to identify men at increased risk for fatal prostate cancer. (Cancer Epidemiol Biomarkers
Prev 2008;17(9):2302–5)</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>DOI: 10.1158/1055-9965.EPI-08-0365</identifier><identifier>PMID: 18768497</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Biological and medical sciences ; calcium ; Calcium - analysis ; cohort study ; Humans ; Incidence ; Male ; Medical sciences ; Middle Aged ; mortality ; Nephrology. Urinary tract diseases ; Nutrition Surveys ; Proportional Hazards Models ; Prospective Studies ; prostate cancer ; Prostatic Neoplasms - blood ; Prostatic Neoplasms - epidemiology ; Prostatic Neoplasms - mortality ; Risk ; Tumors ; Tumors of the urinary system ; United States - epidemiology ; Urinary tract. Prostate gland ; vitamin D</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2008-09, Vol.17 (9), p.2302-2305</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-f8e5837e84076c2a8997da062267214e06978ed3d00ad2fb772d2f4370fc2ba33</citedby><cites>FETCH-LOGICAL-c472t-f8e5837e84076c2a8997da062267214e06978ed3d00ad2fb772d2f4370fc2ba33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,3343,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20625435$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18768497$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SKINNER, Halcyon G</creatorcontrib><creatorcontrib>SCHWARTZ, Gary G</creatorcontrib><title>Serum Calcium and Incident and Fatal Prostate Cancer in the National Health and Nutrition Examination Survey</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>We examined the association between serum calcium levels and the risk for prostate cancer using a prospective cohort, the
National Health and Nutrition Examination Survey (NHANES) and the NHANES Epidemiologic Follow-up Study. Eighty-five incident
cases of prostate cancer and 25 prostate cancer deaths occurred over 46,188 person-years of follow-up. Serum calcium was determined
an average of 9.9 years before the diagnosis of prostate cancer. Comparing men in the top with men in the bottom tertile of
serum calcium, the multivariable-adjusted relative hazard for fatal prostate cancer was 2.68 (95% confidence interval, 1.02-6.99;
P trend = 0.04). For incident prostate cancer, the relative risk for the same comparison was 1.31 (95% confidence interval, 0.77-2.20;
P trend = 0.34). These results support the hypothesis that high serum calcium or a factor strongly associated with it (e.g., high
serum parathyroid hormone) increases the risk for fatal prostate cancer. Our finding of a >2.5-fold increased risk for men
in the highest tertile of serum calcium is comparable in magnitude with the risk associated with family history and could
add significantly to our ability to identify men at increased risk for fatal prostate cancer. (Cancer Epidemiol Biomarkers
Prev 2008;17(9):2302–5)</description><subject>Biological and medical sciences</subject><subject>calcium</subject><subject>Calcium - analysis</subject><subject>cohort study</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>mortality</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nutrition Surveys</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>prostate cancer</subject><subject>Prostatic Neoplasms - blood</subject><subject>Prostatic Neoplasms - epidemiology</subject><subject>Prostatic Neoplasms - mortality</subject><subject>Risk</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>United States - epidemiology</subject><subject>Urinary tract. Prostate gland</subject><subject>vitamin D</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkVtv1DAQhS0Eohf4CaC8gHhJ8SWO7RcktNq2K1WlUuHZmnUmjVEuxXYK_fc4u0uBp7E93xzb5xDyhtEzxqT-yKiUpTG1PFvfbEqqSypq-YwcMyl0qZSUz_P6D3NETmL8TilVRsqX5IhpVevKqGPS32KYh2IFvfO5wtgUm9H5Bse025xDgr64CVNMkDBzo8NQ-LFIHRbXkPw05v4lQp-63cD1nIJfjov1Lxj8uEOK2zk84OMr8qKFPuLrQz0l387XX1eX5dWXi83q81XpKsVT2WqUWijUFVW146CNUQ3QmvNacVYhrY3S2IiGUmh4u1WK51IJRVvHtyDEKfm0172ftwM2Ln8mQG_vgx8gPNoJvP2_M_rO3k0PlquaCrYIvD8IhOnHjDHZwUeHfQ8jTnO0tZGUcmUyKPegyw7FgO3TJYzaJSe7ZGCXDGzOyVJtl5zy3Nt_X_h36hBMBt4dAIgO-jZk43184nh2Q1ZiEfqw5zp_1_30Aa3bRRQwIgTXWaassVxQLn4D49Wq-g</recordid><startdate>20080901</startdate><enddate>20080901</enddate><creator>SKINNER, Halcyon G</creator><creator>SCHWARTZ, Gary G</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080901</creationdate><title>Serum Calcium and Incident and Fatal Prostate Cancer in the National Health and Nutrition Examination Survey</title><author>SKINNER, Halcyon G ; SCHWARTZ, Gary G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-f8e5837e84076c2a8997da062267214e06978ed3d00ad2fb772d2f4370fc2ba33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biological and medical sciences</topic><topic>calcium</topic><topic>Calcium - analysis</topic><topic>cohort study</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>mortality</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nutrition Surveys</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>prostate cancer</topic><topic>Prostatic Neoplasms - blood</topic><topic>Prostatic Neoplasms - epidemiology</topic><topic>Prostatic Neoplasms - mortality</topic><topic>Risk</topic><topic>Tumors</topic><topic>Tumors of the urinary system</topic><topic>United States - epidemiology</topic><topic>Urinary tract. Prostate gland</topic><topic>vitamin D</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SKINNER, Halcyon G</creatorcontrib><creatorcontrib>SCHWARTZ, Gary G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SKINNER, Halcyon G</au><au>SCHWARTZ, Gary G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Calcium and Incident and Fatal Prostate Cancer in the National Health and Nutrition Examination Survey</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2008-09-01</date><risdate>2008</risdate><volume>17</volume><issue>9</issue><spage>2302</spage><epage>2305</epage><pages>2302-2305</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><abstract>We examined the association between serum calcium levels and the risk for prostate cancer using a prospective cohort, the
National Health and Nutrition Examination Survey (NHANES) and the NHANES Epidemiologic Follow-up Study. Eighty-five incident
cases of prostate cancer and 25 prostate cancer deaths occurred over 46,188 person-years of follow-up. Serum calcium was determined
an average of 9.9 years before the diagnosis of prostate cancer. Comparing men in the top with men in the bottom tertile of
serum calcium, the multivariable-adjusted relative hazard for fatal prostate cancer was 2.68 (95% confidence interval, 1.02-6.99;
P trend = 0.04). For incident prostate cancer, the relative risk for the same comparison was 1.31 (95% confidence interval, 0.77-2.20;
P trend = 0.34). These results support the hypothesis that high serum calcium or a factor strongly associated with it (e.g., high
serum parathyroid hormone) increases the risk for fatal prostate cancer. Our finding of a >2.5-fold increased risk for men
in the highest tertile of serum calcium is comparable in magnitude with the risk associated with family history and could
add significantly to our ability to identify men at increased risk for fatal prostate cancer. (Cancer Epidemiol Biomarkers
Prev 2008;17(9):2302–5)</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>18768497</pmid><doi>10.1158/1055-9965.EPI-08-0365</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1055-9965 |
| ispartof | Cancer epidemiology, biomarkers & prevention, 2008-09, Vol.17 (9), p.2302-2305 |
| issn | 1055-9965 1538-7755 |
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| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Biological and medical sciences calcium Calcium - analysis cohort study Humans Incidence Male Medical sciences Middle Aged mortality Nephrology. Urinary tract diseases Nutrition Surveys Proportional Hazards Models Prospective Studies prostate cancer Prostatic Neoplasms - blood Prostatic Neoplasms - epidemiology Prostatic Neoplasms - mortality Risk Tumors Tumors of the urinary system United States - epidemiology Urinary tract. Prostate gland vitamin D |
| title | Serum Calcium and Incident and Fatal Prostate Cancer in the National Health and Nutrition Examination Survey |
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