Intracellular calcium dynamics and acetylcholine-induced triggered activity in the pulmonary veins of dogs with pacing-induced heart failure

Background Heart failure increases autonomic nerve activities and changes intracellular calcium (Cai ) dynamics. Objective The purpose of this study was to investigate the hypothesis that abnormal Cai dynamics are responsible for triggered activity in the pulmonary veins (PVs) during acetylcholine i...

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Veröffentlicht in:	Heart rhythm 2008-08, Vol.5 (8), p.1170-1177
Hauptverfasser:	Chou, Chung-Chuan, MD, Nguyen, Bich Lien, MD, Tan, Alex Y., MD, Chang, Po-Cheng, MD, Lee, Hui-Ling, MD, Lin, Fun-Chung, MD, Yeh, San-Jou, MD, Fishbein, Michael C., MD, Lin, Shien-Fong, PhD, Wu, Delon, MD, Wen, Ming-Shien, MD, Chen, Peng-Sheng, MD, FHRS
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Acetylcholine - administration & dosage Acetylcholine - pharmacology Animals Atrium Calcium Calcium - metabolism Calcium-Transporting ATPases - drug effects Cardiac Pacing, Artificial Cardiovascular Dogs Enzyme Inhibitors - pharmacology Fibrillation Heart failure Heart Failure - etiology Heart Failure - physiopathology Heart Ventricles - drug effects Mapping Models, Animal Pulmonary Veins - drug effects Pulmonary Veins - physiopathology Ryanodine - pharmacology Stroke Volume Thapsigargin - pharmacology Vasodilator Agents - administration & dosage Vasodilator Agents - pharmacology Ventricular Function, Left
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