HDL Remodeling During the Acute Phase Response
OBJECTIVE—The purpose of this study was to examine the interactive action of serum amyloid A (SAA), group IIA secretory phospholipase A2 (sPLA2-IIA), and cholesteryl ester transfer protein (CETP) on HDL remodeling and cholesterol efflux during the acute phase (AP) response elicited in humans after c...
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| Veröffentlicht in: | Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2009-02, Vol.29 (2), p.261-267 |
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| container_title | Arteriosclerosis, thrombosis, and vascular biology |
| container_volume | 29 |
| creator | Jahangiri, Anisa de Beer, Maria C Noffsinger, Victoria Tannock, Lisa R Ramaiah, Chandrashekar Webb, Nancy R van der Westhuyzen, Deneys R de Beer, Frederick C |
| description | OBJECTIVE—The purpose of this study was to examine the interactive action of serum amyloid A (SAA), group IIA secretory phospholipase A2 (sPLA2-IIA), and cholesteryl ester transfer protein (CETP) on HDL remodeling and cholesterol efflux during the acute phase (AP) response elicited in humans after cardiac surgery.
METHODS AND RESULTS—Plasma was collected from patients before (pre-AP), 24 hours after (AP-1 d), and 5 days after cardiac surgery (AP-5 d). SAA levels were increased 16-fold in AP-1 d samples. The activity of sPLA2-IIA was increased from 77.7±38.3 U/mL (pre-AP) to 281.4±57.1 U/mL (AP-1 d; P |
| doi_str_mv | 10.1161/ATVBAHA.108.178681 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2760005</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>19008529</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5438-67f6a6bd00bba72dc21ebdd5d07242f1e3b499561ceba2e528635b5456e081943</originalsourceid><addsrcrecordid>eNpVkVFPwyAUhYnR6Jz-AR_MXnzsvFCg8GJSN3UmSzRGfSW0vbXVrl2g0_jvZdky9QEuN3znkHsg5IzCmFJJL9Pn1-t0lo4pqDFNlFR0jwyoYDziMpb74QyJjoTk7Igce_8OAJwxOCRHVAMowfSAjGfT-egJF12BTd2-jaYrty59haM0X_U4eqysx0D4Zdd6PCEHpW08nm7rkLzc3jxPZtH84e5-ks6jXPBYRTIppZVZAZBlNmFFzihmRSEKSBhnJcU441oLSXPMLEPBlIxFJriQCIpqHg_J1cZ3ucoWWOTY9s42ZunqhXXfprO1-X_T1pV56z4NS2QYUwQDtjHIXee9w3KnpWDW6ZlteqFXZpNeEJ3_ffVXso0rABdbwPrcNqWzbV77HceCl5Y6CRzfcF9d06PzH83qC52p0DZ9Zdb_EEsQEQPQEDaIwqIq_gH-WIcK</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>HDL Remodeling During the Acute Phase Response</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><source>Journals@Ovid Complete</source><creator>Jahangiri, Anisa ; de Beer, Maria C ; Noffsinger, Victoria ; Tannock, Lisa R ; Ramaiah, Chandrashekar ; Webb, Nancy R ; van der Westhuyzen, Deneys R ; de Beer, Frederick C</creator><creatorcontrib>Jahangiri, Anisa ; de Beer, Maria C ; Noffsinger, Victoria ; Tannock, Lisa R ; Ramaiah, Chandrashekar ; Webb, Nancy R ; van der Westhuyzen, Deneys R ; de Beer, Frederick C</creatorcontrib><description>OBJECTIVE—The purpose of this study was to examine the interactive action of serum amyloid A (SAA), group IIA secretory phospholipase A2 (sPLA2-IIA), and cholesteryl ester transfer protein (CETP) on HDL remodeling and cholesterol efflux during the acute phase (AP) response elicited in humans after cardiac surgery.
METHODS AND RESULTS—Plasma was collected from patients before (pre-AP), 24 hours after (AP-1 d), and 5 days after cardiac surgery (AP-5 d). SAA levels were increased 16-fold in AP-1 d samples. The activity of sPLA2-IIA was increased from 77.7±38.3 U/mL (pre-AP) to 281.4±57.1 U/mL (AP-1 d; P<0.001). CETP mass and activity reduction was commensurate to the reduction of HDL cholesterol levels. The combined action of SAA, sPLA2-IIA, and CETP in vitro markedly remodeled HDL with the generation of lipid-poor apoA-I from both pre-AP and AP-1 d HDL. The net result of this remodeling was a relative preservation of ABCA1- and ABCG1-dependent cholesterol efflux during the acute phase response.
CONCLUSIONS—Our results show that the many and complex changes in plasma proteins during the acute phase response markedly remodel HDL with functional implications, particularly the relative retention of cholesterol efflux capacity.</description><identifier>ISSN: 1079-5642</identifier><identifier>EISSN: 1524-4636</identifier><identifier>DOI: 10.1161/ATVBAHA.108.178681</identifier><identifier>PMID: 19008529</identifier><identifier>CODEN: ATVBFA</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Acute-Phase Reaction - blood ; Acute-Phase Reaction - etiology ; Apolipoprotein A-I - blood ; Atherosclerosis (general aspects, experimental research) ; ATP Binding Cassette Transporter 1 ; ATP Binding Cassette Transporter, Sub-Family G, Member 1 ; ATP-Binding Cassette Transporters - blood ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiac Surgical Procedures - adverse effects ; Cardiology. Vascular system ; Cholesterol - blood ; Cholesterol Ester Transfer Proteins - blood ; Chromatography, Affinity ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; General and cellular metabolism. Vitamins ; Group II Phospholipases A2 - blood ; Humans ; Lipoproteins, HDL - blood ; Macrophages - metabolism ; Medical sciences ; Pharmacology. Drug treatments ; Recombinant Proteins - metabolism ; Serum Amyloid A Protein - metabolism ; Time Factors</subject><ispartof>Arteriosclerosis, thrombosis, and vascular biology, 2009-02, Vol.29 (2), p.261-267</ispartof><rights>2009 American Heart Association, Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5438-67f6a6bd00bba72dc21ebdd5d07242f1e3b499561ceba2e528635b5456e081943</citedby><cites>FETCH-LOGICAL-c5438-67f6a6bd00bba72dc21ebdd5d07242f1e3b499561ceba2e528635b5456e081943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21089697$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19008529$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jahangiri, Anisa</creatorcontrib><creatorcontrib>de Beer, Maria C</creatorcontrib><creatorcontrib>Noffsinger, Victoria</creatorcontrib><creatorcontrib>Tannock, Lisa R</creatorcontrib><creatorcontrib>Ramaiah, Chandrashekar</creatorcontrib><creatorcontrib>Webb, Nancy R</creatorcontrib><creatorcontrib>van der Westhuyzen, Deneys R</creatorcontrib><creatorcontrib>de Beer, Frederick C</creatorcontrib><title>HDL Remodeling During the Acute Phase Response</title><title>Arteriosclerosis, thrombosis, and vascular biology</title><addtitle>Arterioscler Thromb Vasc Biol</addtitle><description>OBJECTIVE—The purpose of this study was to examine the interactive action of serum amyloid A (SAA), group IIA secretory phospholipase A2 (sPLA2-IIA), and cholesteryl ester transfer protein (CETP) on HDL remodeling and cholesterol efflux during the acute phase (AP) response elicited in humans after cardiac surgery.
METHODS AND RESULTS—Plasma was collected from patients before (pre-AP), 24 hours after (AP-1 d), and 5 days after cardiac surgery (AP-5 d). SAA levels were increased 16-fold in AP-1 d samples. The activity of sPLA2-IIA was increased from 77.7±38.3 U/mL (pre-AP) to 281.4±57.1 U/mL (AP-1 d; P<0.001). CETP mass and activity reduction was commensurate to the reduction of HDL cholesterol levels. The combined action of SAA, sPLA2-IIA, and CETP in vitro markedly remodeled HDL with the generation of lipid-poor apoA-I from both pre-AP and AP-1 d HDL. The net result of this remodeling was a relative preservation of ABCA1- and ABCG1-dependent cholesterol efflux during the acute phase response.
CONCLUSIONS—Our results show that the many and complex changes in plasma proteins during the acute phase response markedly remodel HDL with functional implications, particularly the relative retention of cholesterol efflux capacity.</description><subject>Acute-Phase Reaction - blood</subject><subject>Acute-Phase Reaction - etiology</subject><subject>Apolipoprotein A-I - blood</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>ATP Binding Cassette Transporter 1</subject><subject>ATP Binding Cassette Transporter, Sub-Family G, Member 1</subject><subject>ATP-Binding Cassette Transporters - blood</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiac Surgical Procedures - adverse effects</subject><subject>Cardiology. Vascular system</subject><subject>Cholesterol - blood</subject><subject>Cholesterol Ester Transfer Proteins - blood</subject><subject>Chromatography, Affinity</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Group II Phospholipases A2 - blood</subject><subject>Humans</subject><subject>Lipoproteins, HDL - blood</subject><subject>Macrophages - metabolism</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Recombinant Proteins - metabolism</subject><subject>Serum Amyloid A Protein - metabolism</subject><subject>Time Factors</subject><issn>1079-5642</issn><issn>1524-4636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkVFPwyAUhYnR6Jz-AR_MXnzsvFCg8GJSN3UmSzRGfSW0vbXVrl2g0_jvZdky9QEuN3znkHsg5IzCmFJJL9Pn1-t0lo4pqDFNlFR0jwyoYDziMpb74QyJjoTk7Igce_8OAJwxOCRHVAMowfSAjGfT-egJF12BTd2-jaYrty59haM0X_U4eqysx0D4Zdd6PCEHpW08nm7rkLzc3jxPZtH84e5-ks6jXPBYRTIppZVZAZBlNmFFzihmRSEKSBhnJcU441oLSXPMLEPBlIxFJriQCIpqHg_J1cZ3ucoWWOTY9s42ZunqhXXfprO1-X_T1pV56z4NS2QYUwQDtjHIXee9w3KnpWDW6ZlteqFXZpNeEJ3_ffVXso0rABdbwPrcNqWzbV77HceCl5Y6CRzfcF9d06PzH83qC52p0DZ9Zdb_EEsQEQPQEDaIwqIq_gH-WIcK</recordid><startdate>200902</startdate><enddate>200902</enddate><creator>Jahangiri, Anisa</creator><creator>de Beer, Maria C</creator><creator>Noffsinger, Victoria</creator><creator>Tannock, Lisa R</creator><creator>Ramaiah, Chandrashekar</creator><creator>Webb, Nancy R</creator><creator>van der Westhuyzen, Deneys R</creator><creator>de Beer, Frederick C</creator><general>American Heart Association, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>200902</creationdate><title>HDL Remodeling During the Acute Phase Response</title><author>Jahangiri, Anisa ; de Beer, Maria C ; Noffsinger, Victoria ; Tannock, Lisa R ; Ramaiah, Chandrashekar ; Webb, Nancy R ; van der Westhuyzen, Deneys R ; de Beer, Frederick C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5438-67f6a6bd00bba72dc21ebdd5d07242f1e3b499561ceba2e528635b5456e081943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acute-Phase Reaction - blood</topic><topic>Acute-Phase Reaction - etiology</topic><topic>Apolipoprotein A-I - blood</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>ATP Binding Cassette Transporter 1</topic><topic>ATP Binding Cassette Transporter, Sub-Family G, Member 1</topic><topic>ATP-Binding Cassette Transporters - blood</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiac Surgical Procedures - adverse effects</topic><topic>Cardiology. Vascular system</topic><topic>Cholesterol - blood</topic><topic>Cholesterol Ester Transfer Proteins - blood</topic><topic>Chromatography, Affinity</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>General and cellular metabolism. Vitamins</topic><topic>Group II Phospholipases A2 - blood</topic><topic>Humans</topic><topic>Lipoproteins, HDL - blood</topic><topic>Macrophages - metabolism</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Recombinant Proteins - metabolism</topic><topic>Serum Amyloid A Protein - metabolism</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jahangiri, Anisa</creatorcontrib><creatorcontrib>de Beer, Maria C</creatorcontrib><creatorcontrib>Noffsinger, Victoria</creatorcontrib><creatorcontrib>Tannock, Lisa R</creatorcontrib><creatorcontrib>Ramaiah, Chandrashekar</creatorcontrib><creatorcontrib>Webb, Nancy R</creatorcontrib><creatorcontrib>van der Westhuyzen, Deneys R</creatorcontrib><creatorcontrib>de Beer, Frederick C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jahangiri, Anisa</au><au>de Beer, Maria C</au><au>Noffsinger, Victoria</au><au>Tannock, Lisa R</au><au>Ramaiah, Chandrashekar</au><au>Webb, Nancy R</au><au>van der Westhuyzen, Deneys R</au><au>de Beer, Frederick C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HDL Remodeling During the Acute Phase Response</atitle><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle><addtitle>Arterioscler Thromb Vasc Biol</addtitle><date>2009-02</date><risdate>2009</risdate><volume>29</volume><issue>2</issue><spage>261</spage><epage>267</epage><pages>261-267</pages><issn>1079-5642</issn><eissn>1524-4636</eissn><coden>ATVBFA</coden><abstract>OBJECTIVE—The purpose of this study was to examine the interactive action of serum amyloid A (SAA), group IIA secretory phospholipase A2 (sPLA2-IIA), and cholesteryl ester transfer protein (CETP) on HDL remodeling and cholesterol efflux during the acute phase (AP) response elicited in humans after cardiac surgery.
METHODS AND RESULTS—Plasma was collected from patients before (pre-AP), 24 hours after (AP-1 d), and 5 days after cardiac surgery (AP-5 d). SAA levels were increased 16-fold in AP-1 d samples. The activity of sPLA2-IIA was increased from 77.7±38.3 U/mL (pre-AP) to 281.4±57.1 U/mL (AP-1 d; P<0.001). CETP mass and activity reduction was commensurate to the reduction of HDL cholesterol levels. The combined action of SAA, sPLA2-IIA, and CETP in vitro markedly remodeled HDL with the generation of lipid-poor apoA-I from both pre-AP and AP-1 d HDL. The net result of this remodeling was a relative preservation of ABCA1- and ABCG1-dependent cholesterol efflux during the acute phase response.
CONCLUSIONS—Our results show that the many and complex changes in plasma proteins during the acute phase response markedly remodel HDL with functional implications, particularly the relative retention of cholesterol efflux capacity.</abstract><cop>Philadelphia, PA</cop><pub>American Heart Association, Inc</pub><pmid>19008529</pmid><doi>10.1161/ATVBAHA.108.178681</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1079-5642 |
| ispartof | Arteriosclerosis, thrombosis, and vascular biology, 2009-02, Vol.29 (2), p.261-267 |
| issn | 1079-5642 1524-4636 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2760005 |
| source | MEDLINE; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Acute-Phase Reaction - blood Acute-Phase Reaction - etiology Apolipoprotein A-I - blood Atherosclerosis (general aspects, experimental research) ATP Binding Cassette Transporter 1 ATP Binding Cassette Transporter, Sub-Family G, Member 1 ATP-Binding Cassette Transporters - blood Biological and medical sciences Blood and lymphatic vessels Cardiac Surgical Procedures - adverse effects Cardiology. Vascular system Cholesterol - blood Cholesterol Ester Transfer Proteins - blood Chromatography, Affinity Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous General and cellular metabolism. Vitamins Group II Phospholipases A2 - blood Humans Lipoproteins, HDL - blood Macrophages - metabolism Medical sciences Pharmacology. Drug treatments Recombinant Proteins - metabolism Serum Amyloid A Protein - metabolism Time Factors |
| title | HDL Remodeling During the Acute Phase Response |
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