HDL Remodeling During the Acute Phase Response

OBJECTIVE—The purpose of this study was to examine the interactive action of serum amyloid A (SAA), group IIA secretory phospholipase A2 (sPLA2-IIA), and cholesteryl ester transfer protein (CETP) on HDL remodeling and cholesterol efflux during the acute phase (AP) response elicited in humans after c...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2009-02, Vol.29 (2), p.261-267
Hauptverfasser:	Jahangiri, Anisa, de Beer, Maria C, Noffsinger, Victoria, Tannock, Lisa R, Ramaiah, Chandrashekar, Webb, Nancy R, van der Westhuyzen, Deneys R, de Beer, Frederick C
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute-Phase Reaction - blood Acute-Phase Reaction - etiology Apolipoprotein A-I - blood Atherosclerosis (general aspects, experimental research) ATP Binding Cassette Transporter 1 ATP Binding Cassette Transporter, Sub-Family G, Member 1 ATP-Binding Cassette Transporters - blood Biological and medical sciences Blood and lymphatic vessels Cardiac Surgical Procedures - adverse effects Cardiology. Vascular system Cholesterol - blood Cholesterol Ester Transfer Proteins - blood Chromatography, Affinity Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous General and cellular metabolism. Vitamins Group II Phospholipases A2 - blood Humans Lipoproteins, HDL - blood Macrophages - metabolism Medical sciences Pharmacology. Drug treatments Recombinant Proteins - metabolism Serum Amyloid A Protein - metabolism Time Factors
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Zusammenfassung:	OBJECTIVE—The purpose of this study was to examine the interactive action of serum amyloid A (SAA), group IIA secretory phospholipase A2 (sPLA2-IIA), and cholesteryl ester transfer protein (CETP) on HDL remodeling and cholesterol efflux during the acute phase (AP) response elicited in humans after cardiac surgery. METHODS AND RESULTS—Plasma was collected from patients before (pre-AP), 24 hours after (AP-1 d), and 5 days after cardiac surgery (AP-5 d). SAA levels were increased 16-fold in AP-1 d samples. The activity of sPLA2-IIA was increased from 77.7±38.3 U/mL (pre-AP) to 281.4±57.1 U/mL (AP-1 d; P
ISSN:	1079-5642 1524-4636
DOI:	10.1161/ATVBAHA.108.178681