Higher Inflammatory Marker Levels in Older Persons: Associations With 5-Year Change in Muscle Mass and Muscle Strength
Background There is growing evidence that higher levels of inflammatory markers are associated with physical decline in older persons, possibly through the catabolic effects of inflammatory markers on muscle. The aim of this study was to investigate the association between serum levels of inflammato...
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| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2009-11, Vol.64A (11), p.1183-1189 |
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| creator | Schaap, Laura A. Pluijm, Saskia M. F. Deeg, Dorly J. H. Harris, Tamara B. Kritchevsky, Stephen B. Newman, Anne B. Colbert, Lisa H. Pahor, Marco Rubin, Susan M. Tylavsky, Frances A. Visser, Marjolein |
| description | Background There is growing evidence that higher levels of inflammatory markers are associated with physical decline in older persons, possibly through the catabolic effects of inflammatory markers on muscle. The aim of this study was to investigate the association between serum levels of inflammatory markers and loss of muscle mass and strength in older persons. Methods Using data on 2,177 men and women in the Health, Aging, and Body Composition Study, we examined 5-year change in thigh muscle area estimated by computed tomography and grip and knee extensor strength in relation to serum levels of interleukin-6 (IL-6), C-reactive protein, tumor necrosis factor-alpha (TNF-α), and soluble receptors (measured in a subsample) at baseline. Results Higher levels of inflammatory markers were generally associated with greater 5-year decline in thigh muscle area. Most associations, with the exception of soluble receptors, were attenuated by adjustment for 5-year change in weight. Higher TNF-α and interleukin-6 soluble receptor levels remained associated with greater decline in grip strength in men. Analyses in a subgroup of weight-stable persons showed that higher levels of TNF-α and its soluble receptors were associated with 5-year decline in thigh muscle area and that higher levels of TNF-α were associated with decline in grip strength. Conclusions TNF-α and its soluble receptors showed the most consistent associations with decline in muscle mass and strength. The results suggest a weight-associated pathway for inflammation in sarcopenia. |
| doi_str_mv | 10.1093/gerona/glp097 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2759573</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/gerona/glp097</oup_id><sourcerecordid>67686787</sourcerecordid><originalsourceid>FETCH-LOGICAL-c483t-c83fdf8bcbe424eb8cf11889e9ae5a93585e2d2238e900ed401b12a562b35a773</originalsourceid><addsrcrecordid>eNqFkUtv1DAUhSMEoqWwZIsiFohNqB_j2GaBVA2PqTRDQQOisLGc5CZxm9iDnYzov8dRhvLY4I197M_n3quTJI8xeoGRpKcNeGf1adPtkOR3kmPMmcgYZZd34xlxmTGE8qPkQQhXaFqM3E-OsMwJEQgfJ_uVaVrw6bmtO933enD-Jt1ofx3v1rCHLqTGphddFfUH8MHZ8DI9C8GVRg8mqvSLGdqUZV9B-3TZatvA9GMzhrKD6BRCqm31S28HD7YZ2ofJvVp3AR4d9pPk89s3n5arbH3x7nx5ts7KhaBDVgpaV7UoygIWZAGFKGuMhZAgNTAtKRMMSEUIFSARgmqBcIGJZjkpKNOc05Pk1ey7G4seqhLs4HWndt702t8op436-8WaVjVurwhnknEaDZ4dDLz7PkIYVG9CCV2nLbgxqJznIudiqvT0H_DKjd7G4RRBIsdc4sktm6HSuxA81LedYKSmONUcp5rjjPyTP9v_TR_yi8DzGXDj7r9eh9omDPDjFo5RxyEoZ2p1-U2hj-8l3m5eqy39CRumvBk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>208617913</pqid></control><display><type>article</type><title>Higher Inflammatory Marker Levels in Older Persons: Associations With 5-Year Change in Muscle Mass and Muscle Strength</title><source>MEDLINE</source><source>Oxford University Press Journals Current</source><source>Alma/SFX Local Collection</source><creator>Schaap, Laura A. ; Pluijm, Saskia M. F. ; Deeg, Dorly J. H. ; Harris, Tamara B. ; Kritchevsky, Stephen B. ; Newman, Anne B. ; Colbert, Lisa H. ; Pahor, Marco ; Rubin, Susan M. ; Tylavsky, Frances A. ; Visser, Marjolein</creator><creatorcontrib>Schaap, Laura A. ; Pluijm, Saskia M. F. ; Deeg, Dorly J. H. ; Harris, Tamara B. ; Kritchevsky, Stephen B. ; Newman, Anne B. ; Colbert, Lisa H. ; Pahor, Marco ; Rubin, Susan M. ; Tylavsky, Frances A. ; Visser, Marjolein ; Health ABC Study ; for the Health ABC Study</creatorcontrib><description>Background There is growing evidence that higher levels of inflammatory markers are associated with physical decline in older persons, possibly through the catabolic effects of inflammatory markers on muscle. The aim of this study was to investigate the association between serum levels of inflammatory markers and loss of muscle mass and strength in older persons. Methods Using data on 2,177 men and women in the Health, Aging, and Body Composition Study, we examined 5-year change in thigh muscle area estimated by computed tomography and grip and knee extensor strength in relation to serum levels of interleukin-6 (IL-6), C-reactive protein, tumor necrosis factor-alpha (TNF-α), and soluble receptors (measured in a subsample) at baseline. Results Higher levels of inflammatory markers were generally associated with greater 5-year decline in thigh muscle area. Most associations, with the exception of soluble receptors, were attenuated by adjustment for 5-year change in weight. Higher TNF-α and interleukin-6 soluble receptor levels remained associated with greater decline in grip strength in men. Analyses in a subgroup of weight-stable persons showed that higher levels of TNF-α and its soluble receptors were associated with 5-year decline in thigh muscle area and that higher levels of TNF-α were associated with decline in grip strength. Conclusions TNF-α and its soluble receptors showed the most consistent associations with decline in muscle mass and strength. The results suggest a weight-associated pathway for inflammation in sarcopenia.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/glp097</identifier><identifier>PMID: 19622801</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Aged ; Aging ; C-Reactive Protein - analysis ; Changes ; Correlation analysis ; Cytokines ; Female ; Hand Strength ; Humans ; Inflammatory markers ; Interleukin-6 - blood ; Journal of Gerontology: Medical Sciences ; Linear Models ; Male ; Muscle ; Muscle Strength ; Muscle, Skeletal - pathology ; Muscular system ; Older people ; Receptors, Interleukin-6 - blood ; Receptors, Tumor Necrosis Factor, Type I - blood ; Studies ; Tomography ; Tumor Necrosis Factor-alpha - blood ; Weight</subject><ispartof>The journals of gerontology. Series A, Biological sciences and medical sciences, 2009-11, Vol.64A (11), p.1183-1189</ispartof><rights>The Author 2009. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org. 2009</rights><rights>Copyright Oxford University Press, UK Nov 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-c83fdf8bcbe424eb8cf11889e9ae5a93585e2d2238e900ed401b12a562b35a773</citedby><cites>FETCH-LOGICAL-c483t-c83fdf8bcbe424eb8cf11889e9ae5a93585e2d2238e900ed401b12a562b35a773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19622801$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schaap, Laura A.</creatorcontrib><creatorcontrib>Pluijm, Saskia M. F.</creatorcontrib><creatorcontrib>Deeg, Dorly J. H.</creatorcontrib><creatorcontrib>Harris, Tamara B.</creatorcontrib><creatorcontrib>Kritchevsky, Stephen B.</creatorcontrib><creatorcontrib>Newman, Anne B.</creatorcontrib><creatorcontrib>Colbert, Lisa H.</creatorcontrib><creatorcontrib>Pahor, Marco</creatorcontrib><creatorcontrib>Rubin, Susan M.</creatorcontrib><creatorcontrib>Tylavsky, Frances A.</creatorcontrib><creatorcontrib>Visser, Marjolein</creatorcontrib><creatorcontrib>Health ABC Study</creatorcontrib><creatorcontrib>for the Health ABC Study</creatorcontrib><title>Higher Inflammatory Marker Levels in Older Persons: Associations With 5-Year Change in Muscle Mass and Muscle Strength</title><title>The journals of gerontology. Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>Background There is growing evidence that higher levels of inflammatory markers are associated with physical decline in older persons, possibly through the catabolic effects of inflammatory markers on muscle. The aim of this study was to investigate the association between serum levels of inflammatory markers and loss of muscle mass and strength in older persons. Methods Using data on 2,177 men and women in the Health, Aging, and Body Composition Study, we examined 5-year change in thigh muscle area estimated by computed tomography and grip and knee extensor strength in relation to serum levels of interleukin-6 (IL-6), C-reactive protein, tumor necrosis factor-alpha (TNF-α), and soluble receptors (measured in a subsample) at baseline. Results Higher levels of inflammatory markers were generally associated with greater 5-year decline in thigh muscle area. Most associations, with the exception of soluble receptors, were attenuated by adjustment for 5-year change in weight. Higher TNF-α and interleukin-6 soluble receptor levels remained associated with greater decline in grip strength in men. Analyses in a subgroup of weight-stable persons showed that higher levels of TNF-α and its soluble receptors were associated with 5-year decline in thigh muscle area and that higher levels of TNF-α were associated with decline in grip strength. Conclusions TNF-α and its soluble receptors showed the most consistent associations with decline in muscle mass and strength. The results suggest a weight-associated pathway for inflammation in sarcopenia.</description><subject>Aged</subject><subject>Aging</subject><subject>C-Reactive Protein - analysis</subject><subject>Changes</subject><subject>Correlation analysis</subject><subject>Cytokines</subject><subject>Female</subject><subject>Hand Strength</subject><subject>Humans</subject><subject>Inflammatory markers</subject><subject>Interleukin-6 - blood</subject><subject>Journal of Gerontology: Medical Sciences</subject><subject>Linear Models</subject><subject>Male</subject><subject>Muscle</subject><subject>Muscle Strength</subject><subject>Muscle, Skeletal - pathology</subject><subject>Muscular system</subject><subject>Older people</subject><subject>Receptors, Interleukin-6 - blood</subject><subject>Receptors, Tumor Necrosis Factor, Type I - blood</subject><subject>Studies</subject><subject>Tomography</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Weight</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAUhSMEoqWwZIsiFohNqB_j2GaBVA2PqTRDQQOisLGc5CZxm9iDnYzov8dRhvLY4I197M_n3quTJI8xeoGRpKcNeGf1adPtkOR3kmPMmcgYZZd34xlxmTGE8qPkQQhXaFqM3E-OsMwJEQgfJ_uVaVrw6bmtO933enD-Jt1ofx3v1rCHLqTGphddFfUH8MHZ8DI9C8GVRg8mqvSLGdqUZV9B-3TZatvA9GMzhrKD6BRCqm31S28HD7YZ2ofJvVp3AR4d9pPk89s3n5arbH3x7nx5ts7KhaBDVgpaV7UoygIWZAGFKGuMhZAgNTAtKRMMSEUIFSARgmqBcIGJZjkpKNOc05Pk1ey7G4seqhLs4HWndt702t8op436-8WaVjVurwhnknEaDZ4dDLz7PkIYVG9CCV2nLbgxqJznIudiqvT0H_DKjd7G4RRBIsdc4sktm6HSuxA81LedYKSmONUcp5rjjPyTP9v_TR_yi8DzGXDj7r9eh9omDPDjFo5RxyEoZ2p1-U2hj-8l3m5eqy39CRumvBk</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>Schaap, Laura A.</creator><creator>Pluijm, Saskia M. F.</creator><creator>Deeg, Dorly J. H.</creator><creator>Harris, Tamara B.</creator><creator>Kritchevsky, Stephen B.</creator><creator>Newman, Anne B.</creator><creator>Colbert, Lisa H.</creator><creator>Pahor, Marco</creator><creator>Rubin, Susan M.</creator><creator>Tylavsky, Frances A.</creator><creator>Visser, Marjolein</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20091101</creationdate><title>Higher Inflammatory Marker Levels in Older Persons: Associations With 5-Year Change in Muscle Mass and Muscle Strength</title><author>Schaap, Laura A. ; Pluijm, Saskia M. F. ; Deeg, Dorly J. H. ; Harris, Tamara B. ; Kritchevsky, Stephen B. ; Newman, Anne B. ; Colbert, Lisa H. ; Pahor, Marco ; Rubin, Susan M. ; Tylavsky, Frances A. ; Visser, Marjolein</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-c83fdf8bcbe424eb8cf11889e9ae5a93585e2d2238e900ed401b12a562b35a773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Aging</topic><topic>C-Reactive Protein - analysis</topic><topic>Changes</topic><topic>Correlation analysis</topic><topic>Cytokines</topic><topic>Female</topic><topic>Hand Strength</topic><topic>Humans</topic><topic>Inflammatory markers</topic><topic>Interleukin-6 - blood</topic><topic>Journal of Gerontology: Medical Sciences</topic><topic>Linear Models</topic><topic>Male</topic><topic>Muscle</topic><topic>Muscle Strength</topic><topic>Muscle, Skeletal - pathology</topic><topic>Muscular system</topic><topic>Older people</topic><topic>Receptors, Interleukin-6 - blood</topic><topic>Receptors, Tumor Necrosis Factor, Type I - blood</topic><topic>Studies</topic><topic>Tomography</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Weight</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schaap, Laura A.</creatorcontrib><creatorcontrib>Pluijm, Saskia M. F.</creatorcontrib><creatorcontrib>Deeg, Dorly J. H.</creatorcontrib><creatorcontrib>Harris, Tamara B.</creatorcontrib><creatorcontrib>Kritchevsky, Stephen B.</creatorcontrib><creatorcontrib>Newman, Anne B.</creatorcontrib><creatorcontrib>Colbert, Lisa H.</creatorcontrib><creatorcontrib>Pahor, Marco</creatorcontrib><creatorcontrib>Rubin, Susan M.</creatorcontrib><creatorcontrib>Tylavsky, Frances A.</creatorcontrib><creatorcontrib>Visser, Marjolein</creatorcontrib><creatorcontrib>Health ABC Study</creatorcontrib><creatorcontrib>for the Health ABC Study</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schaap, Laura A.</au><au>Pluijm, Saskia M. F.</au><au>Deeg, Dorly J. H.</au><au>Harris, Tamara B.</au><au>Kritchevsky, Stephen B.</au><au>Newman, Anne B.</au><au>Colbert, Lisa H.</au><au>Pahor, Marco</au><au>Rubin, Susan M.</au><au>Tylavsky, Frances A.</au><au>Visser, Marjolein</au><aucorp>Health ABC Study</aucorp><aucorp>for the Health ABC Study</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Higher Inflammatory Marker Levels in Older Persons: Associations With 5-Year Change in Muscle Mass and Muscle Strength</atitle><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>64A</volume><issue>11</issue><spage>1183</spage><epage>1189</epage><pages>1183-1189</pages><issn>1079-5006</issn><eissn>1758-535X</eissn><abstract>Background There is growing evidence that higher levels of inflammatory markers are associated with physical decline in older persons, possibly through the catabolic effects of inflammatory markers on muscle. The aim of this study was to investigate the association between serum levels of inflammatory markers and loss of muscle mass and strength in older persons. Methods Using data on 2,177 men and women in the Health, Aging, and Body Composition Study, we examined 5-year change in thigh muscle area estimated by computed tomography and grip and knee extensor strength in relation to serum levels of interleukin-6 (IL-6), C-reactive protein, tumor necrosis factor-alpha (TNF-α), and soluble receptors (measured in a subsample) at baseline. Results Higher levels of inflammatory markers were generally associated with greater 5-year decline in thigh muscle area. Most associations, with the exception of soluble receptors, were attenuated by adjustment for 5-year change in weight. Higher TNF-α and interleukin-6 soluble receptor levels remained associated with greater decline in grip strength in men. Analyses in a subgroup of weight-stable persons showed that higher levels of TNF-α and its soluble receptors were associated with 5-year decline in thigh muscle area and that higher levels of TNF-α were associated with decline in grip strength. Conclusions TNF-α and its soluble receptors showed the most consistent associations with decline in muscle mass and strength. The results suggest a weight-associated pathway for inflammation in sarcopenia.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>19622801</pmid><doi>10.1093/gerona/glp097</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aging C-Reactive Protein - analysis Changes Correlation analysis Cytokines Female Hand Strength Humans Inflammatory markers Interleukin-6 - blood Journal of Gerontology: Medical Sciences Linear Models Male Muscle Muscle Strength Muscle, Skeletal - pathology Muscular system Older people Receptors, Interleukin-6 - blood Receptors, Tumor Necrosis Factor, Type I - blood Studies Tomography Tumor Necrosis Factor-alpha - blood Weight |
| title | Higher Inflammatory Marker Levels in Older Persons: Associations With 5-Year Change in Muscle Mass and Muscle Strength |
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