A-chain of insulin is a hot-spot for CD4⁺ T cell epitopes in human type 1 diabetes

Type 1 diabetes (T1D) is caused by T cell-mediated destruction of the pancreatic insulin-producing β cells. While the role of CD4⁺ T cells in the pathogenesis of T1D is accepted widely, the epitopes recognized by pathogenic human CD4⁺ T cells remain poorly defined. None the less, responses to the N-...

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Veröffentlicht in:	Clinical and experimental immunology 2009-05, Vol.156 (2), p.226-231
Hauptverfasser:	Mannering, S.I, Pang, S.H, Williamson, N.A, Naselli, G, Reynolds, E.C, O'Brien-Simpson, N.M, Purcell, A.W, Harrison, L.C
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Antigen Presentation Biological and medical sciences C-Peptide - chemistry CD4 CD4-Positive T-Lymphocytes - immunology Cysteine - chemistry Diabetes Mellitus, Type 1 - immunology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies epitope Epitope Mapping Epitopes, T-Lymphocyte - chemistry Epitopes, T-Lymphocyte - immunology Etiopathogenesis. Screening. Investigations. Target tissue resistance Fundamental and applied biological sciences. Psychology HLA-DR4 Antigen - immunology Humans Insulin - chemistry Insulin - immunology insulin-dependent diabetes mellitus Medical sciences proinsulin Proinsulin - chemistry Proinsulin - immunology Receptors, Antigen, T-Cell - immunology T cell Translational Studies type 1 diabetes
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