relationship between thyroid function, serum monokine induced by interferon gamma and soluble interleukin-2 receptor in thyroid autoimmune diseases
Interactions between cytokines play an important role in the development of thyroid autoimmunity. Using enzyme-linked immunosorbent assay we investigated serum concentrations of soluble interleukin-2 receptor (sIL-2R), interferon-gamma, tumour necrosis factor (TNF)-α, interleukin (IL)-10, CD30, mono...
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| Veröffentlicht in: | Clinical and experimental immunology 2009-05, Vol.156 (2), p.211-216 |
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| description | Interactions between cytokines play an important role in the development of thyroid autoimmunity. Using enzyme-linked immunosorbent assay we investigated serum concentrations of soluble interleukin-2 receptor (sIL-2R), interferon-gamma, tumour necrosis factor (TNF)-α, interleukin (IL)-10, CD30, monokine induced by interferon-gamma (MIG), cytotoxic T lymphocyte antigen-4 and markers of apoptosis decoy receptor 3 and Bcl-2 in 28 patients with hyperthyroid Graves' disease (GD), 24 patients with untreated Hashimoto's thyroiditis (HT) and 15 healthy controls. TNF-α, IL-10 and sIL-2R were higher in GD compared with HT and controls (TNF-α: 8·79 in GD versus 2·54 pg/ml in HT, P = 0·01; IL-10: 10·00 versus 3·10 versus 3·10 pg/ml, P₁ < 0·001, P₂ = 0·005; sIL-2R: 1·26 versus 0·64 versus 0·46 ng/ml, P < 0·001). MIG and CD30 were higher in HT compared with controls (649·22 ± 262·55 versus 312·95 ± 143·35 pg/ml, P = 0·037, 6·57 ± 2·35 versus 3·03 ± 1·04 U/ml, P = 0·036 respectively). In GD sIL-2R decreased when the euthyroid state was achieved (1·31 ± 0·64 versus 0·260 ± 0·11, n = 12, P < 0·001). sIL-2R correlated positively with free thyroxine (FT4) (R = 0·521, P = 0·000) and negatively with thyroid stimulating hormone (TSH) (R = -0·472, P = 0·00132). MIG correlated negatively with FT4 (R = -0·573, P = 0·00234) and positively with TSH (R = 0·462, P = 0·0179). The results suggest that serum concentrations of sIL-2R and MIG are related to thyroid function rather than to activation of autoimmunity. |
| doi_str_mv | 10.1111/j.1365-2249.2009.03897.x |
| format | Article |
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Using enzyme-linked immunosorbent assay we investigated serum concentrations of soluble interleukin-2 receptor (sIL-2R), interferon-gamma, tumour necrosis factor (TNF)-α, interleukin (IL)-10, CD30, monokine induced by interferon-gamma (MIG), cytotoxic T lymphocyte antigen-4 and markers of apoptosis decoy receptor 3 and Bcl-2 in 28 patients with hyperthyroid Graves' disease (GD), 24 patients with untreated Hashimoto's thyroiditis (HT) and 15 healthy controls. TNF-α, IL-10 and sIL-2R were higher in GD compared with HT and controls (TNF-α: 8·79 in GD versus 2·54 pg/ml in HT, P = 0·01; IL-10: 10·00 versus 3·10 versus 3·10 pg/ml, P₁ < 0·001, P₂ = 0·005; sIL-2R: 1·26 versus 0·64 versus 0·46 ng/ml, P < 0·001). MIG and CD30 were higher in HT compared with controls (649·22 ± 262·55 versus 312·95 ± 143·35 pg/ml, P = 0·037, 6·57 ± 2·35 versus 3·03 ± 1·04 U/ml, P = 0·036 respectively). In GD sIL-2R decreased when the euthyroid state was achieved (1·31 ± 0·64 versus 0·260 ± 0·11, n = 12, P < 0·001). sIL-2R correlated positively with free thyroxine (FT4) (R = 0·521, P = 0·000) and negatively with thyroid stimulating hormone (TSH) (R = -0·472, P = 0·00132). MIG correlated negatively with FT4 (R = -0·573, P = 0·00234) and positively with TSH (R = 0·462, P = 0·0179). The results suggest that serum concentrations of sIL-2R and MIG are related to thyroid function rather than to activation of autoimmunity.</description><identifier>ISSN: 0009-9104</identifier><identifier>EISSN: 1365-2249</identifier><identifier>DOI: 10.1111/j.1365-2249.2009.03897.x</identifier><identifier>PMID: 19250272</identifier><identifier>CODEN: CEXIAL</identifier><language>eng</language><publisher>Oxford, UK: Oxford, UK : Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Analytical, structural and metabolic biochemistry ; Biological and medical sciences ; Case-Control Studies ; CD30 ; Chi-Square Distribution ; Endocrinopathies ; Female ; free thyroxine ; Fundamental and applied biological sciences. Psychology ; Graves Disease - immunology ; Hashimoto Disease - immunology ; Humans ; Interferon-gamma - immunology ; Interleukin-10 - blood ; Male ; Medical sciences ; Middle Aged ; monokine induced by interferon gamma ; Monokines - blood ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Receptors, Interleukin-2 - immunology ; soluble interleukin-2 receptor ; Statistics, Nonparametric ; thyroid autoimmunity ; Thyroid Function Tests ; Thyroid Gland - immunology ; Thyroid Gland - metabolism ; Thyroid. Thyroid axis (diseases) ; Thyroiditis, Autoimmune - immunology ; Thyrotropin - blood ; Thyroxine - blood ; Translational Studies ; Tumor Necrosis Factor-alpha - blood</subject><ispartof>Clinical and experimental immunology, 2009-05, Vol.156 (2), p.211-216</ispartof><rights>2009 British Society for Immunology</rights><rights>2009 INIST-CNRS</rights><rights>Journal Compilation © 2009 British Society for Immunology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6237-1b72ddd0d7494c713b3971e35c4c541ebde8a4815a1bd5f3f4f1c882d40fd56b3</citedby><cites>FETCH-LOGICAL-c6237-1b72ddd0d7494c713b3971e35c4c541ebde8a4815a1bd5f3f4f1c882d40fd56b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759467/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759467/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27915,27916,53782,53784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21336122$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19250272$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiskra, J</creatorcontrib><creatorcontrib>Antošová, M</creatorcontrib><creatorcontrib>Límanová, Z</creatorcontrib><creatorcontrib>Telička, Z</creatorcontrib><creatorcontrib>Lacinová, Z</creatorcontrib><title>relationship between thyroid function, serum monokine induced by interferon gamma and soluble interleukin-2 receptor in thyroid autoimmune diseases</title><title>Clinical and experimental immunology</title><addtitle>Clin Exp Immunol</addtitle><description>Interactions between cytokines play an important role in the development of thyroid autoimmunity. Using enzyme-linked immunosorbent assay we investigated serum concentrations of soluble interleukin-2 receptor (sIL-2R), interferon-gamma, tumour necrosis factor (TNF)-α, interleukin (IL)-10, CD30, monokine induced by interferon-gamma (MIG), cytotoxic T lymphocyte antigen-4 and markers of apoptosis decoy receptor 3 and Bcl-2 in 28 patients with hyperthyroid Graves' disease (GD), 24 patients with untreated Hashimoto's thyroiditis (HT) and 15 healthy controls. TNF-α, IL-10 and sIL-2R were higher in GD compared with HT and controls (TNF-α: 8·79 in GD versus 2·54 pg/ml in HT, P = 0·01; IL-10: 10·00 versus 3·10 versus 3·10 pg/ml, P₁ < 0·001, P₂ = 0·005; sIL-2R: 1·26 versus 0·64 versus 0·46 ng/ml, P < 0·001). MIG and CD30 were higher in HT compared with controls (649·22 ± 262·55 versus 312·95 ± 143·35 pg/ml, P = 0·037, 6·57 ± 2·35 versus 3·03 ± 1·04 U/ml, P = 0·036 respectively). In GD sIL-2R decreased when the euthyroid state was achieved (1·31 ± 0·64 versus 0·260 ± 0·11, n = 12, P < 0·001). sIL-2R correlated positively with free thyroxine (FT4) (R = 0·521, P = 0·000) and negatively with thyroid stimulating hormone (TSH) (R = -0·472, P = 0·00132). MIG correlated negatively with FT4 (R = -0·573, P = 0·00234) and positively with TSH (R = 0·462, P = 0·0179). The results suggest that serum concentrations of sIL-2R and MIG are related to thyroid function rather than to activation of autoimmunity.</description><subject>Adult</subject><subject>Aged</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>CD30</subject><subject>Chi-Square Distribution</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>free thyroxine</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Graves Disease - immunology</subject><subject>Hashimoto Disease - immunology</subject><subject>Humans</subject><subject>Interferon-gamma - immunology</subject><subject>Interleukin-10 - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>monokine induced by interferon gamma</subject><subject>Monokines - blood</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Receptors, Interleukin-2 - immunology</subject><subject>soluble interleukin-2 receptor</subject><subject>Statistics, Nonparametric</subject><subject>thyroid autoimmunity</subject><subject>Thyroid Function Tests</subject><subject>Thyroid Gland - immunology</subject><subject>Thyroid Gland - metabolism</subject><subject>Thyroid. Thyroid axis (diseases)</subject><subject>Thyroiditis, Autoimmune - immunology</subject><subject>Thyrotropin - blood</subject><subject>Thyroxine - blood</subject><subject>Translational Studies</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><issn>0009-9104</issn><issn>1365-2249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAUhSMEotPCK4A3sGqCf2InWVAJjQpUqsQCurYc-2bGQ2IPdkI7z8EL45DRACvwxj_nO_de62QZIrggab3ZFYQJnlNaNgXFuCkwq5uqeHiUrU7C42yFk5Q3BJdn2XmMu3QVQtCn2RlpKMe0oqvsR4Bejda7uLV71MJ4D-DQuD0Ebw3qJqdn8RJFCNOABu_8V-sAWWcmDQa1h3QcIXQQvEMbNQwKKWdQ9P3U9rCIPUzJlFMUQMN-9CE9n1qoafR2GKZU1NgIKkJ8lj3pVB_h-XG_yO7eX39Zf8xvP324Wb-7zbWgrMpJW1FjDDZV2ZS6IqxlTUWAcV1qXhJoDdSqrAlXpDW8Y13ZEV3X1JS4M1y07CK7Wurup3YAo8GNQfVyH-ygwkF6ZeXfirNbufHfJa14U4oqFXh9LBD8twniKAcbNfS9cuCnKEVFOGGE_ROkmNeYE5HAegF18DEG6E7TECzn6OVOzgnLOWE5Ry9_RS8fkvXFn7_5bTxmnYBXR0BFrfouKKdtPHE0zSkInbm3C3dvezj89wByfX0zn5L_5eLvlJdqE1KPu88UE4aJICm5hv0E1h7YdA</recordid><startdate>200905</startdate><enddate>200905</enddate><creator>Jiskra, J</creator><creator>Antošová, M</creator><creator>Límanová, Z</creator><creator>Telička, Z</creator><creator>Lacinová, Z</creator><general>Oxford, UK : Blackwell Publishing Ltd</general><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Blackwell Science Inc</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200905</creationdate><title>relationship between thyroid function, serum monokine induced by interferon gamma and soluble interleukin-2 receptor in thyroid autoimmune diseases</title><author>Jiskra, J ; Antošová, M ; Límanová, Z ; Telička, Z ; Lacinová, Z</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6237-1b72ddd0d7494c713b3971e35c4c541ebde8a4815a1bd5f3f4f1c882d40fd56b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>CD30</topic><topic>Chi-Square Distribution</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>free thyroxine</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Graves Disease - immunology</topic><topic>Hashimoto Disease - immunology</topic><topic>Humans</topic><topic>Interferon-gamma - immunology</topic><topic>Interleukin-10 - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>monokine induced by interferon gamma</topic><topic>Monokines - blood</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Receptors, Interleukin-2 - immunology</topic><topic>soluble interleukin-2 receptor</topic><topic>Statistics, Nonparametric</topic><topic>thyroid autoimmunity</topic><topic>Thyroid Function Tests</topic><topic>Thyroid Gland - immunology</topic><topic>Thyroid Gland - metabolism</topic><topic>Thyroid. Thyroid axis (diseases)</topic><topic>Thyroiditis, Autoimmune - immunology</topic><topic>Thyrotropin - blood</topic><topic>Thyroxine - blood</topic><topic>Translational Studies</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiskra, J</creatorcontrib><creatorcontrib>Antošová, M</creatorcontrib><creatorcontrib>Límanová, Z</creatorcontrib><creatorcontrib>Telička, Z</creatorcontrib><creatorcontrib>Lacinová, Z</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and experimental immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiskra, J</au><au>Antošová, M</au><au>Límanová, Z</au><au>Telička, Z</au><au>Lacinová, Z</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>relationship between thyroid function, serum monokine induced by interferon gamma and soluble interleukin-2 receptor in thyroid autoimmune diseases</atitle><jtitle>Clinical and experimental immunology</jtitle><addtitle>Clin Exp Immunol</addtitle><date>2009-05</date><risdate>2009</risdate><volume>156</volume><issue>2</issue><spage>211</spage><epage>216</epage><pages>211-216</pages><issn>0009-9104</issn><eissn>1365-2249</eissn><coden>CEXIAL</coden><abstract>Interactions between cytokines play an important role in the development of thyroid autoimmunity. Using enzyme-linked immunosorbent assay we investigated serum concentrations of soluble interleukin-2 receptor (sIL-2R), interferon-gamma, tumour necrosis factor (TNF)-α, interleukin (IL)-10, CD30, monokine induced by interferon-gamma (MIG), cytotoxic T lymphocyte antigen-4 and markers of apoptosis decoy receptor 3 and Bcl-2 in 28 patients with hyperthyroid Graves' disease (GD), 24 patients with untreated Hashimoto's thyroiditis (HT) and 15 healthy controls. TNF-α, IL-10 and sIL-2R were higher in GD compared with HT and controls (TNF-α: 8·79 in GD versus 2·54 pg/ml in HT, P = 0·01; IL-10: 10·00 versus 3·10 versus 3·10 pg/ml, P₁ < 0·001, P₂ = 0·005; sIL-2R: 1·26 versus 0·64 versus 0·46 ng/ml, P < 0·001). MIG and CD30 were higher in HT compared with controls (649·22 ± 262·55 versus 312·95 ± 143·35 pg/ml, P = 0·037, 6·57 ± 2·35 versus 3·03 ± 1·04 U/ml, P = 0·036 respectively). In GD sIL-2R decreased when the euthyroid state was achieved (1·31 ± 0·64 versus 0·260 ± 0·11, n = 12, P < 0·001). sIL-2R correlated positively with free thyroxine (FT4) (R = 0·521, P = 0·000) and negatively with thyroid stimulating hormone (TSH) (R = -0·472, P = 0·00132). MIG correlated negatively with FT4 (R = -0·573, P = 0·00234) and positively with TSH (R = 0·462, P = 0·0179). The results suggest that serum concentrations of sIL-2R and MIG are related to thyroid function rather than to activation of autoimmunity.</abstract><cop>Oxford, UK</cop><pub>Oxford, UK : Blackwell Publishing Ltd</pub><pmid>19250272</pmid><doi>10.1111/j.1365-2249.2009.03897.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Analytical, structural and metabolic biochemistry Biological and medical sciences Case-Control Studies CD30 Chi-Square Distribution Endocrinopathies Female free thyroxine Fundamental and applied biological sciences. Psychology Graves Disease - immunology Hashimoto Disease - immunology Humans Interferon-gamma - immunology Interleukin-10 - blood Male Medical sciences Middle Aged monokine induced by interferon gamma Monokines - blood Non tumoral diseases. Target tissue resistance. Benign neoplasms Receptors, Interleukin-2 - immunology soluble interleukin-2 receptor Statistics, Nonparametric thyroid autoimmunity Thyroid Function Tests Thyroid Gland - immunology Thyroid Gland - metabolism Thyroid. Thyroid axis (diseases) Thyroiditis, Autoimmune - immunology Thyrotropin - blood Thyroxine - blood Translational Studies Tumor Necrosis Factor-alpha - blood |
| title | relationship between thyroid function, serum monokine induced by interferon gamma and soluble interleukin-2 receptor in thyroid autoimmune diseases |
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