Involvement of functional polymorphisms in the TNFA gene in the pathogenesis of autoimmune thyroid diseases and production of anti-thyrotropin receptor antibody

The severity of Hashimoto's disease (HD) and intractability of Graves' disease (GD) varies among patients. Severity of HD is associated with the functional +874A/T polymorphism for interferon-γ, an inflammatory cytokine. To clarify the association between functional polymorphisms in two ot...

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Veröffentlicht in:	Clinical and experimental immunology 2009-05, Vol.156 (2), p.199-204
Hauptverfasser:	Inoue, N, Watanabe, M, Nanba, T, Wada, M, Akamizu, T, Iwatani, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adult Analytical, structural and metabolic biochemistry Autoantibodies - blood Biological and medical sciences Case-Control Studies Chi-Square Distribution disease severity Endocrinopathies Female Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease Genotype Graves Disease - genetics Graves Disease - immunology Hashimoto Disease - genetics Hashimoto Disease - immunology Humans IL-2 Interferon-gamma - genetics Interleukin-2 - genetics Iodide Peroxidase - immunology Male Medical sciences Middle Aged Non tumoral diseases. Target tissue resistance. Benign neoplasms Polymorphism, Single Nucleotide Prognosis Receptors, Thyrotropin - immunology single nucleotide polymorphism Statistics, Nonparametric Thyroglobulin - immunology Thyroid. Thyroid axis (diseases) TNF-α TRAb Translational Studies Tumor Necrosis Factor-alpha - genetics
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