Control of fetal hemoglobin: new insights emerging from genomics and clinical implications

Increased levels of fetal hemoglobin (HbF, α2γ2) are of no consequence in healthy adults, but confer major clinical benefits in patients with sickle cell anemia (SCA) and β thalassemia, diseases that represent major public health problems. Inter-individual HbF variation is largely genetically contro...

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Veröffentlicht in:	Human molecular genetics 2009-10, Vol.18 (R2), p.R216-R223
Hauptverfasser:	Thein, Swee Lay, Menzel, Stephan, Lathrop, Mark, Garner, Chad
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Diverse techniques Erythrocytes - metabolism Erythrocytes - pathology Fetal Hemoglobin - genetics Fundamental and applied biological sciences. Psychology Genetic Variation Genetics of eukaryotes. Biological and molecular evolution Genomics Humans Molecular and cellular biology Quantitative Trait Loci - genetics Quantitative Trait, Heritable Reviews
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