Changes in feeding and locomotion induced by amphetamine analogs in rats
Abstract Studies of the biobehavioral actions of psychostimulants commonly focus on locomotion and less commonly on feeding, and only rarely are these measures considered in conjunction within the same animal. The present study compared the impact of (+)-amphetamine and three amphetamine analogs, PA...
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| description | Abstract Studies of the biobehavioral actions of psychostimulants commonly focus on locomotion and less commonly on feeding, and only rarely are these measures considered in conjunction within the same animal. The present study compared the impact of (+)-amphetamine and three amphetamine analogs, PAL-287, PAL-313, and PAL-353, on eating and locomotion assessed concurrently using an automated activity/feeding chamber during a daily 45 min session. Each analog is a potent releaser of norepinephrine and of dopamine, but exerts differential serotonin-releasing activity (PAL-287 > PAL-313 > amphetamine > PAL-353). Rats were tested with each of five doses of drug (0, 2, 4, 8, or 16 μmol/kg, i.p.), given in equimolar concentrations and in random dose order. PAL-353, an analog with minimal serotonin-releasing capacity, markedly stimulated forward locomotion at 2, 4, 8 and 16 μmol/kg, as did amphetamine, whereas PAL-287 and PAL-313 did not. In contrast to the locomotor findings, all four amphetamine-like drugs exerted similar effects on the suppression of food intake. These results suggest that the capacity of an amphetamine analog (i.e. amphetamine and PAL-353) to stimulate serotonin release can diminish its psychostimulant action on locomotion, but does not reliably augment drug-induced hypophagia. |
| doi_str_mv | 10.1016/j.drugalcdep.2008.10.005 |
| format | Article |
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Shane ; Rothman, Richard B ; Blough, Bruce E</creator><creatorcontrib>Wellman, Paul J ; Davis, Kristina W ; Clifford, P. Shane ; Rothman, Richard B ; Blough, Bruce E</creatorcontrib><description>Abstract Studies of the biobehavioral actions of psychostimulants commonly focus on locomotion and less commonly on feeding, and only rarely are these measures considered in conjunction within the same animal. The present study compared the impact of (+)-amphetamine and three amphetamine analogs, PAL-287, PAL-313, and PAL-353, on eating and locomotion assessed concurrently using an automated activity/feeding chamber during a daily 45 min session. Each analog is a potent releaser of norepinephrine and of dopamine, but exerts differential serotonin-releasing activity (PAL-287 > PAL-313 > amphetamine > PAL-353). Rats were tested with each of five doses of drug (0, 2, 4, 8, or 16 μmol/kg, i.p.), given in equimolar concentrations and in random dose order. PAL-353, an analog with minimal serotonin-releasing capacity, markedly stimulated forward locomotion at 2, 4, 8 and 16 μmol/kg, as did amphetamine, whereas PAL-287 and PAL-313 did not. In contrast to the locomotor findings, all four amphetamine-like drugs exerted similar effects on the suppression of food intake. These results suggest that the capacity of an amphetamine analog (i.e. amphetamine and PAL-353) to stimulate serotonin release can diminish its psychostimulant action on locomotion, but does not reliably augment drug-induced hypophagia.</description><identifier>ISSN: 0376-8716</identifier><identifier>EISSN: 1879-0046</identifier><identifier>DOI: 10.1016/j.drugalcdep.2008.10.005</identifier><identifier>PMID: 19062203</identifier><identifier>CODEN: DADEDV</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Addictive behaviors ; Adult and adolescent clinical studies ; Amphetamine ; Amphetamine - chemistry ; Amphetamine - pharmacology ; Amphetamines ; Animals ; Biological and medical sciences ; Body weight ; Cumulative food intake ; Drug addiction ; Feeding Behavior - drug effects ; Feeding Behavior - physiology ; Food consumption ; Male ; Medical sciences ; Monoamine ; Motor Activity - drug effects ; Motor Activity - physiology ; Neuropharmacology ; Neurotransmitters ; Pharmacology. Drug treatments ; Psychiatry ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychopharmacology ; Rats ; Rats, Sprague-Dawley</subject><ispartof>Drug and alcohol dependence, 2009-03, Vol.100 (3), p.234-239</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2008 Elsevier Ireland Ltd</rights><rights>2009 INIST-CNRS</rights><rights>Elsevier Ireland Ltd. 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Shane</creatorcontrib><creatorcontrib>Rothman, Richard B</creatorcontrib><creatorcontrib>Blough, Bruce E</creatorcontrib><title>Changes in feeding and locomotion induced by amphetamine analogs in rats</title><title>Drug and alcohol dependence</title><addtitle>Drug Alcohol Depend</addtitle><description>Abstract Studies of the biobehavioral actions of psychostimulants commonly focus on locomotion and less commonly on feeding, and only rarely are these measures considered in conjunction within the same animal. The present study compared the impact of (+)-amphetamine and three amphetamine analogs, PAL-287, PAL-313, and PAL-353, on eating and locomotion assessed concurrently using an automated activity/feeding chamber during a daily 45 min session. Each analog is a potent releaser of norepinephrine and of dopamine, but exerts differential serotonin-releasing activity (PAL-287 > PAL-313 > amphetamine > PAL-353). Rats were tested with each of five doses of drug (0, 2, 4, 8, or 16 μmol/kg, i.p.), given in equimolar concentrations and in random dose order. PAL-353, an analog with minimal serotonin-releasing capacity, markedly stimulated forward locomotion at 2, 4, 8 and 16 μmol/kg, as did amphetamine, whereas PAL-287 and PAL-313 did not. In contrast to the locomotor findings, all four amphetamine-like drugs exerted similar effects on the suppression of food intake. These results suggest that the capacity of an amphetamine analog (i.e. amphetamine and PAL-353) to stimulate serotonin release can diminish its psychostimulant action on locomotion, but does not reliably augment drug-induced hypophagia.</description><subject>Addictive behaviors</subject><subject>Adult and adolescent clinical studies</subject><subject>Amphetamine</subject><subject>Amphetamine - chemistry</subject><subject>Amphetamine - pharmacology</subject><subject>Amphetamines</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body weight</subject><subject>Cumulative food intake</subject><subject>Drug addiction</subject><subject>Feeding Behavior - drug effects</subject><subject>Feeding Behavior - physiology</subject><subject>Food consumption</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Monoamine</subject><subject>Motor Activity - drug effects</subject><subject>Motor Activity - physiology</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychiatry</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>0376-8716</issn><issn>1879-0046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqNkk9vEzEQxVcIREPhK6C9wC1h7F3_u1SCCChSJQ7A2XLs2cRh1w72bqV8-3pJ1AKX4oslv9-Mn_2mqmoCKwKEv9uvXJq2prcODysKIMvxCoA9qRZECrUEaPnTagGN4EspCL-oXuS8h7K4gufVBVHAKYVmUV2vdyZsMdc-1B2i82Fbm-DqPto4xNHHUBQ3WXT15lib4bDD0Qw-YKFMH7e_C5MZ88vqWWf6jK_O-2X149PH7-vr5c3Xz1_W72-Wtlw9Lhln1gAnUjVSdI0ioIpJha3tKMqiMsUpp2JjOXNStMopBoRK5njDrWHNZXV16nuYNgM6i2FMpteH5AeTjjoar_9Wgt_pbbzVVDDJoS0N3p4bpPhrwjzqwWeLfW8CxilrzmVDCXkcZIIKQVv-KFg-WioAWkB5Am2KOSfs7m0T0HOweq8fgtVzsLNSgi2lr_989kPhOckCvDkDJlvTd8kE6_M9RwllgqjZ7IcThyWkW49JZ-sxlIB9QjtqF_3_uLn6p4ntffDl3p94xLyPUyrTkTXRmWrQ3-ZBnOcQJEDDBTR3ycbaBg</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>Wellman, Paul J</creator><creator>Davis, Kristina W</creator><creator>Clifford, P. 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Drug treatments</topic><topic>Psychiatry</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wellman, Paul J</creatorcontrib><creatorcontrib>Davis, Kristina W</creatorcontrib><creatorcontrib>Clifford, P. 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Each analog is a potent releaser of norepinephrine and of dopamine, but exerts differential serotonin-releasing activity (PAL-287 > PAL-313 > amphetamine > PAL-353). Rats were tested with each of five doses of drug (0, 2, 4, 8, or 16 μmol/kg, i.p.), given in equimolar concentrations and in random dose order. PAL-353, an analog with minimal serotonin-releasing capacity, markedly stimulated forward locomotion at 2, 4, 8 and 16 μmol/kg, as did amphetamine, whereas PAL-287 and PAL-313 did not. In contrast to the locomotor findings, all four amphetamine-like drugs exerted similar effects on the suppression of food intake. 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| subjects | Addictive behaviors Adult and adolescent clinical studies Amphetamine Amphetamine - chemistry Amphetamine - pharmacology Amphetamines Animals Biological and medical sciences Body weight Cumulative food intake Drug addiction Feeding Behavior - drug effects Feeding Behavior - physiology Food consumption Male Medical sciences Monoamine Motor Activity - drug effects Motor Activity - physiology Neuropharmacology Neurotransmitters Pharmacology. Drug treatments Psychiatry Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Rats Rats, Sprague-Dawley |
| title | Changes in feeding and locomotion induced by amphetamine analogs in rats |
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