LIG Family Receptor Tyrosine Kinase-Associated Proteins Modulate Growth Factor Signals during Neural Development

Genome-wide screens were performed to identify transmembrane proteins that mediate axonal growth, guidance and target field innervation of somatosensory neurons. One gene, Linx (alias Islr2), encoding a leucine-rich repeat and immunoglobulin (LIG) family protein, is expressed in a subset of developi...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2009-09, Vol.63 (5), p.614-627
Hauptverfasser:	Mandai, Kenji, Guo, Ting, St. Hillaire, Coryse, Meabon, James S., Kanning, Kevin C., Bothwell, Mark, Ginty, David D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DEVBIO Ganglia, Spinal - embryology Ganglia, Spinal - growth & development Ganglia, Spinal - metabolism Intercellular Signaling Peptides and Proteins - metabolism Ligands Mice Mice, Knockout MOLNEURO Motor Neurons - physiology Musculoskeletal system Nerve Growth Factor - genetics Nerve Growth Factor - metabolism Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurons Neurons - physiology Neurotrophin 3 - genetics Neurotrophin 3 - metabolism Peripheral Nervous System - embryology Peripheral Nervous System - growth & development Peripheral Nervous System - metabolism Proto-Oncogene Proteins c-ret - metabolism Receptor Protein-Tyrosine Kinases - metabolism Receptor, trkA - metabolism Receptors, Nerve Growth Factor - metabolism Rodents Sensory Receptor Cells - physiology Sequence Analysis, DNA Sequence Homology SIGNALING Spinal Cord - embryology Spinal Cord - growth & development Spinal Cord - metabolism Target recognition
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