Polymer-Enhanced Adenoviral Transduction of CAR-Negative Bladder Cancer Cells

The application of adenoviral gene therapy for cancer is limited by immune clearance of the virus as well as poor transduction efficiency, since the protein used for viral entry (CAR) serves physiological functions in adhesion and is frequently decreased among cancer cells. Cationic polymers have be...

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Veröffentlicht in:	Molecular pharmaceutics 2009-10, Vol.6 (5), p.1612-1619
Hauptverfasser:	Kasman, Laura M, Barua, Sutapa, Lu, Ping, Rege, Kaushal, Voelkel-Johnson, Christina
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenovirus Adenoviruses, Human - genetics Cell Death Cell Line, Tumor Coxsackie and Adenovirus Receptor-Like Membrane Protein Epoxy Resins - chemistry Gene Expression Genetic Therapy - methods Genetic Vectors Green Fluorescent Proteins - genetics Humans Polymers - chemistry Receptors, Virus - deficiency Receptors, Virus - genetics Receptors, Virus - metabolism Recombinant Proteins - genetics TNF-Related Apoptosis-Inducing Ligand - genetics Transduction, Genetic - methods Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - therapy
Online-Zugang:	Volltext
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