Role of Schlafen 2 (SLFN2) in the Generation of Interferon α-induced Growth Inhibitory Responses

The precise STAT-regulated gene targets that inhibit cell growth and generate the antitumor effects of Type I interferons (IFNs) remain unknown. We provide evidence that Type I IFNs regulate expression of Schlafens (SLFNs), a group of genes involved in the control of cell cycle progression and growt...

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Veröffentlicht in:	The Journal of biological chemistry 2009-09, Vol.284 (37), p.25051-25064
Hauptverfasser:	Katsoulidis, Efstratios, Carayol, Nathalie, Woodard, Jennifer, Konieczna, Iwona, Majchrzak-Kita, Beata, Jordan, Alison, Sassano, Antonella, Eklund, Elizabeth A., Fish, Eleanor N., Platanias, Leonidas C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle Cell Cycle Proteins - metabolism Cell Cycle Proteins - physiology Cell Line Cell Proliferation CpG Islands Cytokines - metabolism Hematopoietic Stem Cells - cytology Interferon-alpha - metabolism MAP Kinase Signaling System Mechanisms of Signal Transduction Mice Mice, Transgenic NIH 3T3 Cells p38 Mitogen-Activated Protein Kinases - metabolism STAT1 Transcription Factor - metabolism
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