Cell Polarity Factor Par3 Binds SPTLC1 and Modulates Monocyte Serine Palmitoyltransferase Activity and Chemotaxis

Elevated sphingolipids have been associated with increased cardiovascular disease. Conversely, atherosclerosis is reduced in mice by blocking de novo synthesis of sphingolipids catalyzed by serine palmitoyltransferase (SPT). The SPT enzyme is composed of the SPTLC1 and -2 subunits, and here we descr...

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Veröffentlicht in:	The Journal of biological chemistry 2009-09, Vol.284 (37), p.24881-24890
Hauptverfasser:	Tamehiro, Norimasa, Mujawar, Zahedi, Zhou, Suiping, Zhuang, Debbie Z., Hornemann, Thorsten, von Eckardstein, Arnold, Fitzgerald, Michael L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Amino Acid Motifs Amino Acid Sequence Cell Cycle Proteins - metabolism Cell Line Cell Movement Chemotaxis Humans Inflammation Lipids and Lipoproteins: Metabolism, Regulation, and Signaling Membrane Proteins - metabolism Molecular Sequence Data Monocytes - cytology Monocytes - metabolism Protein Structure, Tertiary Sequence Homology, Amino Acid Serine C-Palmitoyltransferase - metabolism Sphingolipids - metabolism
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