T cell Immunoglobulin Mucin Protein (TIM)-4 binds phosphatidylserine and mediates uptake of apoptotic cells

The T cell immunoglobulin mucin (TIM) proteins regulate T cell activation and tolerance. Both TIM-4, expressed on human and mouse macrophages and dendritic cells, and TIM-1 specifically bind to phosphatidylserine (PS) on the surface of apoptotic cells and do not bind to any other phospholipid tested...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2007-12, Vol.27 (6), p.927-940
Hauptverfasser:	Kobayashi, Norimoto, Karisola, Piia, Peña-Cruz, Victor, Dorfman, David M., Jinushi, Masahisa, Umetsu, Sarah E., Butte, Manish J., Nagumo, Haruo, Chernova, Irene, Zhu, Baogong, Sharpe, Arlene H., Ito, Susumu, Dranoff, Glenn, Kaplan, Gerardo G., Casasnovas, Jose M., Umetsu, Dale T., DeKruyff, Rosemarie H., Freeman, Gordon J.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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