Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases
Metastasis is the deadliest phase of cancer progression. Experimental models using immunodeficient mice have been used to gain insights into the mechanisms of metastasis. We report here the identification of a “metastasis aggressiveness gene expression signature” derived using human melanoma cells s...
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| Veröffentlicht in: | Molecular cancer research 2008-05, Vol.6 (5), p.760-769 |
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| container_title | Molecular cancer research |
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| creator | Xu, Lei Shen, Steven S Hoshida, Yujin Subramanian, Aravind Ross, Ken Brunet, Jean-Philippe Wagner, Stephan N Ramaswamy, Sridhar Mesirov, Jill P Hynes, Richard O |
| description | Metastasis is the deadliest phase of cancer progression. Experimental models using immunodeficient mice have been used to
gain insights into the mechanisms of metastasis. We report here the identification of a “metastasis aggressiveness gene expression
signature” derived using human melanoma cells selected based on their metastatic potentials in a xenotransplant metastasis
model. Comparison with expression data from human melanoma patients shows that this metastasis gene signature correlates with
the aggressiveness of melanoma metastases in human patients. Many genes encoding secreted and membrane proteins are included
in the signature, suggesting the importance of tumor-microenvironment interactions during metastasis. (Mol Cancer Res 2008;6(5):760–9) |
| doi_str_mv | 10.1158/1541-7786.MCR-07-0344 |
| format | Article |
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gain insights into the mechanisms of metastasis. We report here the identification of a “metastasis aggressiveness gene expression
signature” derived using human melanoma cells selected based on their metastatic potentials in a xenotransplant metastasis
model. Comparison with expression data from human melanoma patients shows that this metastasis gene signature correlates with
the aggressiveness of melanoma metastases in human patients. Many genes encoding secreted and membrane proteins are included
in the signature, suggesting the importance of tumor-microenvironment interactions during metastasis. (Mol Cancer Res 2008;6(5):760–9)</description><identifier>ISSN: 1541-7786</identifier><identifier>EISSN: 1557-3125</identifier><identifier>DOI: 10.1158/1541-7786.MCR-07-0344</identifier><identifier>PMID: 18505921</identifier><language>eng</language><publisher>United States: American Association for Cancer Research</publisher><subject>Animal Model ; Animals ; Cell Line, Tumor ; Disease Models, Animal ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Gene Signature ; Humans ; Melanoma ; Melanoma - pathology ; Metastasis ; Mice ; Mice, SCID ; Microarray ; Models, Biological ; Neoplasm Metastasis ; Neoplasm Transplantation ; Treatment Outcome</subject><ispartof>Molecular cancer research, 2008-05, Vol.6 (5), p.760-769</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c523t-bf18f09acedf202275d966d8c0820eddc63b41d2d8d29314c67253e48e88b0963</citedby><cites>FETCH-LOGICAL-c523t-bf18f09acedf202275d966d8c0820eddc63b41d2d8d29314c67253e48e88b0963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,3356,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18505921$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Lei</creatorcontrib><creatorcontrib>Shen, Steven S</creatorcontrib><creatorcontrib>Hoshida, Yujin</creatorcontrib><creatorcontrib>Subramanian, Aravind</creatorcontrib><creatorcontrib>Ross, Ken</creatorcontrib><creatorcontrib>Brunet, Jean-Philippe</creatorcontrib><creatorcontrib>Wagner, Stephan N</creatorcontrib><creatorcontrib>Ramaswamy, Sridhar</creatorcontrib><creatorcontrib>Mesirov, Jill P</creatorcontrib><creatorcontrib>Hynes, Richard O</creatorcontrib><title>Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases</title><title>Molecular cancer research</title><addtitle>Mol Cancer Res</addtitle><description>Metastasis is the deadliest phase of cancer progression. Experimental models using immunodeficient mice have been used to
gain insights into the mechanisms of metastasis. We report here the identification of a “metastasis aggressiveness gene expression
signature” derived using human melanoma cells selected based on their metastatic potentials in a xenotransplant metastasis
model. Comparison with expression data from human melanoma patients shows that this metastasis gene signature correlates with
the aggressiveness of melanoma metastases in human patients. Many genes encoding secreted and membrane proteins are included
in the signature, suggesting the importance of tumor-microenvironment interactions during metastasis. (Mol Cancer Res 2008;6(5):760–9)</description><subject>Animal Model</subject><subject>Animals</subject><subject>Cell Line, Tumor</subject><subject>Disease Models, Animal</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Gene Signature</subject><subject>Humans</subject><subject>Melanoma</subject><subject>Melanoma - pathology</subject><subject>Metastasis</subject><subject>Mice</subject><subject>Mice, SCID</subject><subject>Microarray</subject><subject>Models, Biological</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasm Transplantation</subject><subject>Treatment Outcome</subject><issn>1541-7786</issn><issn>1557-3125</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1rFDEYhQdRbK3-BCVX3k19k5l8zI2wDLUtdBFEr0M2eedDZpI1mW3135uxS1evhEBCcs7Je3iK4i2FS0q5-kB5TUsplbjctl9KkCVUdf2sOKecy7KijD9fz0fNWfEqpe8ADKgUL4szqjjwhtHzwl-jR3L1cx8xpTF40g7G95jI6InxZOPH2Uxki5PxYTZkGxxOpA0x5psFycO4DGTT93_c9zkqJRI6cnOYs_nkwsWkvDC9Ll50Zkr45rhfFN8-XX1tb8q7z9e37eautJxVS7nrqOqgMRZdx4AxyV0jhFMWFAN0zopqV1PHnHKsqWhthWS8wlqhUjtoRHVRfHzM3R92MzqLfolm0vuY68RfOphR__vix0H34V7nr0TT0Bzw_hgQw48DpkXPY7I45UYYDklLkLLm8H8hA4CG1pCF_FFoY0gpYvc0DQW9ItUrLr3i0hmpBqlXpNn37u8qJ9eR4WmCYeyHhzGitsZbzIgSmmgHLTTXUkD1G_zGrFQ</recordid><startdate>20080501</startdate><enddate>20080501</enddate><creator>Xu, Lei</creator><creator>Shen, Steven S</creator><creator>Hoshida, Yujin</creator><creator>Subramanian, Aravind</creator><creator>Ross, Ken</creator><creator>Brunet, Jean-Philippe</creator><creator>Wagner, Stephan N</creator><creator>Ramaswamy, Sridhar</creator><creator>Mesirov, Jill P</creator><creator>Hynes, Richard O</creator><general>American Association for Cancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080501</creationdate><title>Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases</title><author>Xu, Lei ; Shen, Steven S ; Hoshida, Yujin ; Subramanian, Aravind ; Ross, Ken ; Brunet, Jean-Philippe ; Wagner, Stephan N ; Ramaswamy, Sridhar ; Mesirov, Jill P ; Hynes, Richard O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c523t-bf18f09acedf202275d966d8c0820eddc63b41d2d8d29314c67253e48e88b0963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animal Model</topic><topic>Animals</topic><topic>Cell Line, Tumor</topic><topic>Disease Models, Animal</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Gene Signature</topic><topic>Humans</topic><topic>Melanoma</topic><topic>Melanoma - pathology</topic><topic>Metastasis</topic><topic>Mice</topic><topic>Mice, SCID</topic><topic>Microarray</topic><topic>Models, Biological</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasm Transplantation</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Lei</creatorcontrib><creatorcontrib>Shen, Steven S</creatorcontrib><creatorcontrib>Hoshida, Yujin</creatorcontrib><creatorcontrib>Subramanian, Aravind</creatorcontrib><creatorcontrib>Ross, Ken</creatorcontrib><creatorcontrib>Brunet, Jean-Philippe</creatorcontrib><creatorcontrib>Wagner, Stephan N</creatorcontrib><creatorcontrib>Ramaswamy, Sridhar</creatorcontrib><creatorcontrib>Mesirov, Jill P</creatorcontrib><creatorcontrib>Hynes, Richard O</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Lei</au><au>Shen, Steven S</au><au>Hoshida, Yujin</au><au>Subramanian, Aravind</au><au>Ross, Ken</au><au>Brunet, Jean-Philippe</au><au>Wagner, Stephan N</au><au>Ramaswamy, Sridhar</au><au>Mesirov, Jill P</au><au>Hynes, Richard O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases</atitle><jtitle>Molecular cancer research</jtitle><addtitle>Mol Cancer Res</addtitle><date>2008-05-01</date><risdate>2008</risdate><volume>6</volume><issue>5</issue><spage>760</spage><epage>769</epage><pages>760-769</pages><issn>1541-7786</issn><eissn>1557-3125</eissn><abstract>Metastasis is the deadliest phase of cancer progression. Experimental models using immunodeficient mice have been used to
gain insights into the mechanisms of metastasis. We report here the identification of a “metastasis aggressiveness gene expression
signature” derived using human melanoma cells selected based on their metastatic potentials in a xenotransplant metastasis
model. Comparison with expression data from human melanoma patients shows that this metastasis gene signature correlates with
the aggressiveness of melanoma metastases in human patients. Many genes encoding secreted and membrane proteins are included
in the signature, suggesting the importance of tumor-microenvironment interactions during metastasis. (Mol Cancer Res 2008;6(5):760–9)</abstract><cop>United States</cop><pub>American Association for Cancer Research</pub><pmid>18505921</pmid><doi>10.1158/1541-7786.MCR-07-0344</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Animal Model Animals Cell Line, Tumor Disease Models, Animal Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Signature Humans Melanoma Melanoma - pathology Metastasis Mice Mice, SCID Microarray Models, Biological Neoplasm Metastasis Neoplasm Transplantation Treatment Outcome |
| title | Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases |
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