Neuroinflammation and cognitive function in aged mice following minor surgery

Following surgery, elderly patients often suffer from postoperative cognitive dysfunction (POCD) which can persist long after physical recovery. It is known that surgery-induced tissue damage activates the peripheral innate immune system resulting in the release of inflammatory mediators. Compared t...

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Veröffentlicht in:	Experimental gerontology 2008-09, Vol.43 (9), p.840-846
Hauptverfasser:	Rosczyk, H.A., Sparkman, N.L., Johnson, R.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - immunology Aging - physiology Aging - psychology Analgesics - pharmacology Anesthetics - pharmacology Animals Brain Cognition Disorders - immunology Cytokines Cytokines - biosynthesis Cytokines - genetics Hippocampus - drug effects Hippocampus - immunology Interleukin-1beta - biosynthesis Interleukin-1beta - genetics Male Maze Learning Memory, Short-Term Mice Mice, Inbred BALB C Minor Surgical Procedures Motor Activity Neurogenic Inflammation - immunology Neurogenic Inflammation - psychology Neuroimmunomodulation POCD Postoperative Complications - immunology RNA, Messenger - genetics Working memory
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