A cellular model of inflammation for identifying TNF-α synthesis inhibitors

Neuroinflammation is a common facet of both acute and chronic neurodegenerative conditions, exemplified by stroke and by Alzheimer's and Parkinson's disease, and the presence of elevated levels of the proinflammatory cytokine, tumor necrosis factor-α (TNF-α), has been documented in each. A...

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Veröffentlicht in:	Journal of neuroscience methods 2009-10, Vol.183 (2), p.182-187
Hauptverfasser:	Tweedie, David, Luo, Weiming, Short, Ryan G., Brossi, Arnold, Holloway, Harold W., Li, Yazhou, Yu, Qian-sheng, Greig, Nigel H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animals Cell Line, Transformed Cell Proliferation - drug effects Cell Survival - drug effects Disease Models, Animal Dose-Response Relationship, Drug Immunosuppressive Agents - chemistry Immunosuppressive Agents - pharmacology Inflammation - chemically induced Inflammation - drug therapy Inflammation - metabolism Lenalidomide Lipopolysaccharide (LPS) Lipopolysaccharides - pharmacology Male Mice Neurodegeneration Neuroinflammation Rats Rats, Inbred F344 RAW 264.7 Statistics, Nonparametric Thalidomide Thalidomide - analogs & derivatives Thalidomide - chemistry Thalidomide - pharmacology Time Factors TNF-α Tumor Necrosis Factor-alpha - metabolism
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