Integration of Genomic and Genetic Approaches Implicates IREB2 as a COPD Susceptibility Gene

Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide and is influenced by both genetic determinants and smoking. We identified genomic regions from 56 lung-tissue gene-expression microarrays and used them to select 889 SNPs to be tested for association with COP...

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Veröffentlicht in:	American journal of human genetics 2009-10, Vol.85 (4), p.493-502
Hauptverfasser:	DeMeo, Dawn L., Mariani, Thomas, Bhattacharya, Soumyaroop, Srisuma, Sorachai, Lange, Christoph, Litonjua, Augusto, Bueno, Raphael, Pillai, Sreekumar G., Lomas, David A., Sparrow, David, Shapiro, Steven D., Criner, Gerard J., Kim, Hong P., Chen, Zhihua, Choi, Augustine M.K., Reilly, John, Silverman, Edwin K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Case-Control Studies Chronic obstructive pulmonary disease Cohort Studies Epithelial Cells - metabolism Family Health Female Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Profiling General aspects. Genetic counseling Genetic Predisposition to Disease Genetics of eukaryotes. Biological and molecular evolution Genomics Genotype & phenotype Humans Iron Regulatory Protein 2 - genetics Lung - metabolism Male Medical genetics Medical sciences Middle Aged Models, Genetic Molecular and cellular biology Polymorphism, Single Nucleotide Pulmonary Disease, Chronic Obstructive - diagnosis Pulmonary Disease, Chronic Obstructive - genetics Ribonucleic acid RNA Smoking
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