Rostral ventral medulla cholinergic mechanism in pain-induced analgesia
The ascending nociceptive control (ANC), a novel spinostriatal pain modulation pathway, mediates a form of pain-induced analgesia referred to as noxious stimulus-induced antinociception (NSIA). ANC includes specific spinal cord mechanisms as well as circuitry in nucleus accumbens, a major component...
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| Veröffentlicht in: | Neuroscience letters 2009-10, Vol.464 (3), p.170-172 |
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| container_title | Neuroscience letters |
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| creator | Gear, Robert W. Levine, Jon D. |
| description | The ascending nociceptive control (ANC), a novel spinostriatal pain modulation pathway, mediates a form of pain-induced analgesia referred to as noxious stimulus-induced antinociception (NSIA). ANC includes specific spinal cord mechanisms as well as circuitry in nucleus accumbens, a major component of the ventral striatum. Here, using the trigeminal jaw-opening reflex (JOR) in the rat as a nociceptive assay, we show that microinjection of the nicotinic acetylcholine receptor (nAChR) antagonist mecamylamine into the rostral ventral medulla (RVM) blocks NSIA, implicating RVM as a potentially important link between ANC and the PAG–RVM–spinal descending pain modulation system. A circuit connecting nucleus accumbens to the RVM is proposed as a novel striato-RVM pathway. |
| doi_str_mv | 10.1016/j.neulet.2009.08.036 |
| format | Article |
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ANC includes specific spinal cord mechanisms as well as circuitry in nucleus accumbens, a major component of the ventral striatum. Here, using the trigeminal jaw-opening reflex (JOR) in the rat as a nociceptive assay, we show that microinjection of the nicotinic acetylcholine receptor (nAChR) antagonist mecamylamine into the rostral ventral medulla (RVM) blocks NSIA, implicating RVM as a potentially important link between ANC and the PAG–RVM–spinal descending pain modulation system. A circuit connecting nucleus accumbens to the RVM is proposed as a novel striato-RVM pathway.</description><subject>Acetylcholine</subject><subject>Analgesia</subject><subject>Animals</subject><subject>Antinociception</subject><subject>Electromyography</subject><subject>Male</subject><subject>Mecamylamine - administration & dosage</subject><subject>Mecamylamine - pharmacology</subject><subject>Medulla Oblongata - metabolism</subject><subject>Microinjections</subject><subject>Neural Pathways</subject><subject>Nicotinic Antagonists - administration & dosage</subject><subject>Nicotinic Antagonists - pharmacology</subject><subject>Noxious stimulation</subject><subject>Nucleus accumbens</subject><subject>Pain - metabolism</subject><subject>Pain - physiopathology</subject><subject>Pain Measurement</subject><subject>Pedunculopontine tegmental nucleus</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Nicotinic - physiology</subject><subject>Reflex</subject><subject>Trigeminal Nerve - physiopathology</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1r3DAUFCWl2ab9B6X4lJvdJ1mfl0AIaVoIFEp7Fs-yvKvFK28keyH_vkp3aZpLexp4mjeaeUPIBwoNBSo_bZvol9HPDQMwDegGWvmKrKhWrFZGsTOyghZ43RoO5-RtzlsAEFTwN-ScGmkMk3pF7r5PeU44Vgcff-PO98s4YuU20xiiT-vgysxtMIa8q0Ks9hhiHWK_ON9XGHFc-xzwHXk94Jj9-xNekJ-fb3_cfKnvv919vbm-rx03bK5VN2gYFCijuw6xQ42qo0L0yByTZmjblkvgBQYtDLIy5m0ntOcDSsOwvSBXR9390hWr7uja7lPYYXq0Ewb78iWGjV1PB8uUkJyKInB5EkjTw-LzbHchO18iRz8t2Uolheac_5fIKCihQBciPxJdmnJOfvjjhoJ9qspu7bEq-1SVBW1LVWXt499JnpdO3TxH9eWeh-CTzS74WM4eknez7afw7x9-AXnBqN0</recordid><startdate>20091030</startdate><enddate>20091030</enddate><creator>Gear, Robert W.</creator><creator>Levine, Jon D.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20091030</creationdate><title>Rostral ventral medulla cholinergic mechanism in pain-induced analgesia</title><author>Gear, Robert W. ; Levine, Jon D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-7bf80f70798bbaaba8a7b155da2c269f3334604333f859a2a2c43b58e4fa692a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acetylcholine</topic><topic>Analgesia</topic><topic>Animals</topic><topic>Antinociception</topic><topic>Electromyography</topic><topic>Male</topic><topic>Mecamylamine - administration & dosage</topic><topic>Mecamylamine - pharmacology</topic><topic>Medulla Oblongata - metabolism</topic><topic>Microinjections</topic><topic>Neural Pathways</topic><topic>Nicotinic Antagonists - administration & dosage</topic><topic>Nicotinic Antagonists - pharmacology</topic><topic>Noxious stimulation</topic><topic>Nucleus accumbens</topic><topic>Pain - metabolism</topic><topic>Pain - physiopathology</topic><topic>Pain Measurement</topic><topic>Pedunculopontine tegmental nucleus</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Nicotinic - physiology</topic><topic>Reflex</topic><topic>Trigeminal Nerve - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gear, Robert W.</creatorcontrib><creatorcontrib>Levine, Jon D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gear, Robert W.</au><au>Levine, Jon D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rostral ventral medulla cholinergic mechanism in pain-induced analgesia</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2009-10-30</date><risdate>2009</risdate><volume>464</volume><issue>3</issue><spage>170</spage><epage>172</epage><pages>170-172</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><abstract>The ascending nociceptive control (ANC), a novel spinostriatal pain modulation pathway, mediates a form of pain-induced analgesia referred to as noxious stimulus-induced antinociception (NSIA). 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| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 2009-10, Vol.464 (3), p.170-172 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Acetylcholine Analgesia Animals Antinociception Electromyography Male Mecamylamine - administration & dosage Mecamylamine - pharmacology Medulla Oblongata - metabolism Microinjections Neural Pathways Nicotinic Antagonists - administration & dosage Nicotinic Antagonists - pharmacology Noxious stimulation Nucleus accumbens Pain - metabolism Pain - physiopathology Pain Measurement Pedunculopontine tegmental nucleus Rats Rats, Sprague-Dawley Receptors, Nicotinic - physiology Reflex Trigeminal Nerve - physiopathology |
| title | Rostral ventral medulla cholinergic mechanism in pain-induced analgesia |
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